Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 788464..789157 Replicon chromosome
Accession NZ_CP058748
Organism Escherichia coli strain STLIN_13

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZS99_RS03830 Protein ID WP_000415584.1
Coordinates 788464..788760 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZS99_RS03835 Protein ID WP_000650107.1
Coordinates 788762..789157 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS99_RS03795 (783552) 783552..783866 - 315 WP_000958598.1 putative quinol monooxygenase -
HZS99_RS03800 (783897) 783897..784478 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZS99_RS03805 (784797) 784797..785129 + 333 WP_023149630.1 DUF2645 family protein -
HZS99_RS03810 (785175) 785175..786524 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
HZS99_RS03815 (786521) 786521..787180 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZS99_RS03820 (787332) 787332..787724 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZS99_RS03825 (787777) 787777..788259 + 483 WP_000183505.1 GyrI-like domain-containing protein -
HZS99_RS03830 (788464) 788464..788760 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZS99_RS03835 (788762) 788762..789157 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZS99_RS03840 (789290) 789290..790897 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZS99_RS03845 (791035) 791035..793293 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167336 WP_000415584.1 NZ_CP058748:788464-788760 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167336 NZ_CP075115:3252988-3253206 [Salmonella enterica subsp. enterica serovar Eastbourne]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCAGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167336 WP_000650107.1 NZ_CP058748:788762-789157 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167336 NZ_CP075115:3252586-3252960 [Salmonella enterica subsp. enterica serovar Eastbourne]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References