Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3884702..3885299 Replicon chromosome
Accession NZ_CP058743
Organism Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag HZS96_RS19305 Protein ID WP_004893639.1
Coordinates 3884982..3885299 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HZS96_RS19300 Protein ID WP_004142561.1
Coordinates 3884702..3884989 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS96_RS19270 (3880909) 3880909..3881157 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HZS96_RS19275 (3881175) 3881175..3881516 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HZS96_RS19280 (3881547) 3881547..3882662 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
HZS96_RS19285 (3882842) 3882842..3883423 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
HZS96_RS19290 (3883423) 3883423..3883791 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
HZS96_RS19295 (3883911) 3883911..3884564 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HZS96_RS19300 (3884702) 3884702..3884989 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HZS96_RS19305 (3884982) 3884982..3885299 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS96_RS19310 (3885484) 3885484..3886527 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
HZS96_RS19315 (3887197) 3887197..3888063 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
HZS96_RS19320 (3888172) 3888172..3889599 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-100)

Antitoxin

(38-88)


Sequences


Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T167324 WP_004893639.1 NZ_CP058743:c3885299-3884982 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T167324 NZ_CP075113:c4236747-4236463 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGATTAA
GAAAAAGTTGGCTGATGTGCTATTGGACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT167324 WP_004142561.1 NZ_CP058743:c3884989-3884702 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT167324 NZ_CP075113:c4236979-4236737 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References