Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 730605..731380 Replicon chromosome
Accession NZ_CP058743
Organism Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag HZS96_RS03615 Protein ID WP_004150910.1
Coordinates 730895..731380 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HZS96_RS03610 Protein ID WP_004150912.1
Coordinates 730605..730898 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS96_RS03590 (725813) 725813..726415 - 603 WP_002916735.1 short chain dehydrogenase -
HZS96_RS03595 (726513) 726513..727424 + 912 WP_004188550.1 LysR family transcriptional regulator -
HZS96_RS03600 (727425) 727425..728573 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
HZS96_RS03605 (728584) 728584..729960 - 1377 WP_004217775.1 cystathionine beta-synthase -
HZS96_RS03610 (730605) 730605..730898 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HZS96_RS03615 (730895) 730895..731380 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
HZS96_RS03620 (732084) 732084..732677 + 594 WP_004188553.1 hypothetical protein -
HZS96_RS03625 (732774) 732774..732990 + 217 Protein_712 transposase -
HZS96_RS03630 (733597) 733597..734469 + 873 WP_004188557.1 ParA family protein -
HZS96_RS03635 (734469) 734469..734852 + 384 WP_004150906.1 hypothetical protein -
HZS96_RS03640 (734845) 734845..736212 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 732774..732926 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T167313 WP_004150910.1 NZ_CP058743:730895-731380 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T167313 NZ_CP075113:199935-200420 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT167313 WP_004150912.1 NZ_CP058743:730605-730898 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT167313 NZ_CP075113:199660-199947 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References