Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 284760..285279 Replicon chromosome
Accession NZ_CP058741
Organism Streptococcus suis strain 13-00283-02

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag SSU1300283_RS01440 Protein ID WP_002939009.1
Coordinates 285022..285279 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag SSU1300283_RS01435 Protein ID WP_002939010.1
Coordinates 284760..285020 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU1300283_RS01420 281188..282804 + 1617 WP_024375787.1 recombinase family protein -
SSU1300283_RS01425 282797..284233 + 1437 WP_024410048.1 recombinase family protein -
SSU1300283_RS01430 284343..284684 + 342 Protein_262 8-oxo-dGTP diphosphatase -
SSU1300283_RS01435 284760..285020 + 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SSU1300283_RS01440 285022..285279 + 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
SSU1300283_RS01445 285293..285823 + 531 WP_002939008.1 DUF1697 domain-containing protein -
SSU1300283_RS01450 285807..286715 + 909 WP_074390583.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSU1300283_RS01455 286918..288648 + 1731 WP_024390921.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) - 222409..285551 63142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T167302 WP_002939009.1 NZ_CP058741:285022-285279 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

>T167302 NZ_CP075112:856446-856859 [Salmonella enterica subsp. enterica serovar Corvallis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT167302 WP_002939010.1 NZ_CP058741:284760-285020 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT167302 NZ_CP075112:856199-856465 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References