Detailed information of TA system TA167290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 30414..30840
• Replicon: plasmid pS171-1.1
• Accession: NZ_CP058726
• Organism: Escherichia coli strain S171-1

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HZS87_RS22430
• Protein ID: WP_001372321.1
• Coordinates: 30414..30539 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	30616..30840 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS87_RS22385 (25460)	25460..25687	-	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-
HZS87_RS22390 (25781)	25781..26467	-	687	WP_000332484.1	PAS domain-containing protein	-
HZS87_RS22395 (26658)	26658..27041	-	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HZS87_RS22400 (27318)	27318..27965	+	648	WP_000614936.1	transglycosylase SLT domain-containing protein	-
HZS87_RS22405 (28262)	28262..29083	-	822	WP_001234469.1	DUF932 domain-containing protein	-
HZS87_RS22410 (29205)	29205..29492	-	288	WP_000107535.1	hypothetical protein	-
HZS87_RS22415 (29517)	29517..29723	-	207	WP_000547939.1	hypothetical protein	-
HZS87_RS22420 (29793)	29793..29966	+	174	Protein_37	hypothetical protein	-
HZS87_RS22425 (29964)	29964..30194	-	231	WP_001426396.1	hypothetical protein	-
HZS87_RS22430 (30414)	30414..30539	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZS87_RS22435 (30481)	30481..30630	-	150	Protein_40	plasmid maintenance protein Mok	-
- (30616)	30616..30840	-	225	NuclAT_0	-	Antitoxin
- (30616)	30616..30840	-	225	NuclAT_0	-	Antitoxin
- (30616)	30616..30840	-	225	NuclAT_0	-	Antitoxin
- (30616)	30616..30840	-	225	NuclAT_0	-	Antitoxin
HZS87_RS22440 (30652)	30652..30840	+	189	WP_001299721.1	hypothetical protein	-
HZS87_RS22445 (30809)	30809..31571	-	763	Protein_42	plasmid SOS inhibition protein A	-
HZS87_RS22450 (31568)	31568..32002	-	435	WP_000845895.1	conjugation system SOS inhibitor PsiB	-
HZS87_RS22455 (32057)	32057..34015	-	1959	WP_001145469.1	ParB/RepB/Spo0J family partition protein	-
HZS87_RS22460 (34074)	34074..34307	-	234	WP_000006004.1	DUF905 domain-containing protein	-
HZS87_RS22465 (34363)	34363..34890	-	528	WP_000290793.1	single-stranded DNA-binding protein	-
HZS87_RS22470 (35363)	35363..35629	-	267	WP_072254135.1	hypothetical protein	-
HZS87_RS22475 (35533)	35533..35781	-	249	WP_012311402.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD / dfrA14 / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1A / aac(3)-IId	iroB / iroC / iroD / iroE / iroN	1..152180	152180

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T167290 WP_001372321.1 NZ_CP058726:c30539-30414 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167290 NZ_CP075110:1993210-1993313 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 225 bp

>AT167290 NZ_CP058726:c30840-30616 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin