Detailed information of TA system TA167280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 909802..910440
• Replicon: chromosome
• Accession: NZ_CP058725
• Organism: Escherichia coli strain S171-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: HZS87_RS04460
• Protein ID: WP_000813794.1
• Coordinates: 910264..910440 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZS87_RS04455
• Protein ID: WP_001270286.1
• Coordinates: 909802..910218 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS87_RS04435 (904954)	904954..905895	-	942	WP_001251319.1	ABC transporter permease	-
HZS87_RS04440 (905896)	905896..906909	-	1014	WP_000220393.1	ABC transporter ATP-binding protein	-
HZS87_RS04445 (906927)	906927..908072	-	1146	WP_000047418.1	ABC transporter substrate-binding protein	-
HZS87_RS04450 (908317)	908317..909723	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
HZS87_RS04455 (909802)	909802..910218	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HZS87_RS04460 (910264)	910264..910440	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HZS87_RS04465 (910662)	910662..910892	+	231	WP_000494244.1	YncJ family protein	-
HZS87_RS04470 (910984)	910984..912945	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HZS87_RS04475 (913018)	913018..913554	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
HZS87_RS04480 (913646)	913646..914821	+	1176	WP_001236265.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP020543 Escherichia coli C IS/Tn TA075073 2433298..2434446 0.007	flank	IS/Tn	-	-	914861..916009	1148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T167280 WP_000813794.1 NZ_CP058725:c910440-910264 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T167280 NZ_CP058725:c910440-910264 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT167280 WP_001270286.1 NZ_CP058725:c910218-909802 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT167280 NZ_CP058725:c910218-909802 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• PDB: 6HPB