Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 364138..364831 Replicon chromosome
Accession NZ_CP058719
Organism Escherichia coli strain M159-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HZS86_RS01765 Protein ID WP_000415584.1
Coordinates 364535..364831 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HZS86_RS01760 Protein ID WP_000650107.1
Coordinates 364138..364533 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS86_RS01750 (360002) 360002..362260 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
HZS86_RS01755 (362398) 362398..364005 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HZS86_RS01760 (364138) 364138..364533 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HZS86_RS01765 (364535) 364535..364831 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HZS86_RS01770 (365036) 365036..365518 - 483 WP_000183505.1 GyrI-like domain-containing protein -
HZS86_RS01775 (365571) 365571..365963 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HZS86_RS01780 (366115) 366115..366774 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
HZS86_RS01785 (366771) 366771..368120 + 1350 WP_130062318.1 quorum sensing histidine kinase QseC -
HZS86_RS01790 (368166) 368166..368498 - 333 WP_000917684.1 DUF2645 family protein -
HZS86_RS01795 (368817) 368817..369398 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HZS86_RS01800 (369429) 369429..369743 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T167244 WP_000415584.1 NZ_CP058719:c364831-364535 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T167244 NZ_CP075106:2067252-2067355 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT167244 WP_000650107.1 NZ_CP058719:c364533-364138 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT167244 NZ_CP075106:c2067357-2067212 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References