Detailed information of TA system TA167236

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 109173..109442
• Replicon: plasmid pM172-1.1
• Accession: NZ_CP058715
• Organism: Escherichia coli strain M172-1

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HYI45_RS24625
• Protein ID: WP_001372321.1
• Coordinates: 109317..109442 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	109173..109238 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYI45_RS24580 (104248)	104248..104475	+	228	WP_071594011.1	hypothetical protein	-
HYI45_RS24585 (104716)	104716..104922	+	207	WP_000547971.1	hypothetical protein	-
HYI45_RS24590 (104948)	104948..105487	+	540	WP_000290812.1	single-stranded DNA-binding protein	-
HYI45_RS24595 (105549)	105549..105782	+	234	WP_072855056.1	DUF905 domain-containing protein	-
HYI45_RS24600 (105841)	105841..107799	+	1959	WP_239795023.1	ParB/RepB/Spo0J family partition protein	-
HYI45_RS24605 (107854)	107854..108288	+	435	WP_000845895.1	conjugation system SOS inhibitor PsiB	-
HYI45_RS24610 (108285)	108285..109047	+	763	Protein_140	plasmid SOS inhibition protein A	-
HYI45_RS24615 (109016)	109016..109204	-	189	WP_001299721.1	hypothetical protein	-
- (109173)	109173..109238	+	66	NuclAT_3	-	-
- (109016)	109016..109240	+	225	NuclAT_1	-	-
- (109016)	109016..109240	+	225	NuclAT_1	-	-
- (109016)	109016..109240	+	225	NuclAT_1	-	-
- (109016)	109016..109240	+	225	NuclAT_1	-	-
- (109016)	109016..109240	-	225	NuclAT_0	-	-
HYI45_RS24620 (109226)	109226..109375	+	150	Protein_142	plasmid maintenance protein Mok	-
HYI45_RS24625 (109317)	109317..109442	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HYI45_RS24630 (109662)	109662..109892	+	231	WP_071587244.1	hypothetical protein	-
HYI45_RS24635 (109890)	109890..110063	-	174	Protein_145	hypothetical protein	-
HYI45_RS24640 (110133)	110133..110339	+	207	WP_000547971.1	hypothetical protein	-
HYI45_RS24645 (110364)	110364..110651	+	288	WP_000107535.1	hypothetical protein	-
HYI45_RS24650 (110769)	110769..111590	+	822	WP_001234469.1	DUF932 domain-containing protein	-
HYI45_RS24655 (111887)	111887..112534	-	648	WP_130568609.1	transglycosylase SLT domain-containing protein	-
HYI45_RS24660 (112810)	112810..112980	+	171	Protein_150	conjugal transfer relaxosome DNA-binding protein TraM	-
HYI45_RS24665 (112996)	112996..113772	+	777	Protein_151	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..126040	126040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T167236 WP_001372321.1 NZ_CP058715:109317-109442 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167236 NZ_CP075067:57598-57852 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT167236 NZ_CP058715:c109238-109173 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin