Detailed information of TA system TA167233

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 42130..42399
• Replicon: plasmid pM172-1.1
• Accession: NZ_CP058715
• Organism: Escherichia coli strain M172-1

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: HYI45_RS24185
• Protein ID: WP_001372321.1
• Coordinates: 42274..42399 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	42130..42195 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYI45_RS24140 (37205)	37205..37432	+	228	WP_071594011.1	hypothetical protein	-
HYI45_RS24145 (37673)	37673..37879	+	207	WP_000547971.1	hypothetical protein	-
HYI45_RS24150 (37905)	37905..38444	+	540	WP_000290812.1	single-stranded DNA-binding protein	-
HYI45_RS24155 (38506)	38506..38739	+	234	WP_072855056.1	DUF905 domain-containing protein	-
HYI45_RS24160 (38798)	38798..40756	+	1959	WP_239795023.1	ParB/RepB/Spo0J family partition protein	-
HYI45_RS24165 (40811)	40811..41245	+	435	WP_000845895.1	conjugation system SOS inhibitor PsiB	-
HYI45_RS24170 (41242)	41242..42004	+	763	Protein_52	plasmid SOS inhibition protein A	-
HYI45_RS24175 (41973)	41973..42161	-	189	WP_001299721.1	hypothetical protein	-
- (42130)	42130..42195	+	66	NuclAT_2	-	-
- (41973)	41973..42197	+	225	NuclAT_0	-	-
- (41973)	41973..42197	+	225	NuclAT_0	-	-
- (41973)	41973..42197	+	225	NuclAT_0	-	-
- (41973)	41973..42197	+	225	NuclAT_0	-	-
- (41973)	41973..42197	-	225	NuclAT_1	-	-
HYI45_RS24180 (42183)	42183..42332	+	150	Protein_54	plasmid maintenance protein Mok	-
HYI45_RS24185 (42274)	42274..42399	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
HYI45_RS24190 (42619)	42619..42849	+	231	WP_071587244.1	hypothetical protein	-
HYI45_RS24195 (42847)	42847..43020	-	174	Protein_57	hypothetical protein	-
HYI45_RS24200 (43090)	43090..43296	+	207	WP_000547971.1	hypothetical protein	-
HYI45_RS24205 (43321)	43321..43608	+	288	WP_000107535.1	hypothetical protein	-
HYI45_RS24210 (43726)	43726..44547	+	822	WP_001234469.1	DUF932 domain-containing protein	-
HYI45_RS24215 (44844)	44844..45491	-	648	WP_130568609.1	transglycosylase SLT domain-containing protein	-
HYI45_RS24220 (45767)	45767..46150	+	384	WP_001151533.1	conjugal transfer relaxosome DNA-binding protein TraM	-
HYI45_RS24225 (46342)	46342..46989	+	648	WP_072855064.1	conjugal transfer transcriptional regulator TraJ	-
HYI45_RS24230 (47125)	47125..47340	+	216	WP_000086380.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..126040	126040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T167233 WP_001372321.1 NZ_CP058715:42274-42399 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T167233 NZ_CP075063:85763-86161 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT167233 NZ_CP058715:c42195-42130 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin