Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 1879346..1880040 | Replicon | chromosome |
| Accession | NZ_CP058709 | ||
| Organism | Escherichia coli strain S163-2 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | HZS88_RS09590 | Protein ID | WP_001263493.1 |
| Coordinates | 1879346..1879744 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | HZS88_RS09595 | Protein ID | WP_000554757.1 |
| Coordinates | 1879747..1880040 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (1874887) | 1874887..1874967 | - | 81 | NuclAT_12 | - | - |
| - (1874887) | 1874887..1874967 | - | 81 | NuclAT_12 | - | - |
| - (1874887) | 1874887..1874967 | - | 81 | NuclAT_12 | - | - |
| - (1874887) | 1874887..1874967 | - | 81 | NuclAT_12 | - | - |
| HZS88_RS09560 (1875563) | 1875563..1876021 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| HZS88_RS09565 (1876282) | 1876282..1877739 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
| HZS88_RS09570 (1877796) | 1877796..1878317 | - | 522 | Protein_1880 | peptide chain release factor H | - |
| HZS88_RS09575 (1878316) | 1878316..1878510 | - | 195 | Protein_1881 | RtcB family protein | - |
| HZS88_RS09580 (1878560) | 1878560..1879257 | + | 698 | WP_151351650.1 | IS1-like element IS1A family transposase | - |
| HZS88_RS09585 (1879274) | 1879274..1879336 | - | 63 | Protein_1883 | GNAT family N-acetyltransferase | - |
| HZS88_RS09590 (1879346) | 1879346..1879744 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| HZS88_RS09595 (1879747) | 1879747..1880040 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| HZS88_RS09600 (1880092) | 1880092..1881147 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
| HZS88_RS09605 (1881218) | 1881218..1882141 | - | 924 | WP_001468020.1 | putative lateral flagellar export/assembly protein LafU | - |
| HZS88_RS09610 (1882144) | 1882144..1883007 | - | 864 | WP_001169518.1 | flagellar motor stator protein MotA | - |
| HZS88_RS09615 (1883020) | 1883020..1883739 | - | 720 | WP_000938740.1 | FliA/WhiG family RNA polymerase sigma factor | - |
| HZS88_RS09620 (1883759) | 1883759..1884226 | - | 468 | WP_000725257.1 | flagellar basal body-associated FliL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1878754..1879257 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T167194 WP_001263493.1 NZ_CP058709:c1879744-1879346 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T167194 NZ_CP075059:c52728-52348 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAAATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAAATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT167194 WP_000554757.1 NZ_CP058709:c1880040-1879747 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT167194 NZ_CP075059:c52949-52728 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGCTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGCTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|