Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3745415..3746169 | Replicon | chromosome |
| Accession | NZ_CP058671 | ||
| Organism | Salmonella enterica strain MS114 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A3V4SQJ3 |
| Locus tag | HWV51_RS18155 | Protein ID | WP_000558164.1 |
| Coordinates | 3745415..3745726 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HWV51_RS18160 | Protein ID | WP_001259011.1 |
| Coordinates | 3745723..3746169 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWV51_RS18125 (3741073) | 3741073..3741975 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| HWV51_RS18130 (3741972) | 3741972..3742607 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| HWV51_RS18135 (3742604) | 3742604..3743533 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| HWV51_RS18140 (3743580) | 3743580..3743870 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| HWV51_RS18145 (3743871) | 3743871..3744182 | - | 312 | WP_001159632.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| HWV51_RS18150 (3744400) | 3744400..3745329 | + | 930 | WP_001127700.1 | alpha/beta hydrolase | - |
| HWV51_RS18155 (3745415) | 3745415..3745726 | + | 312 | WP_000558164.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| HWV51_RS18160 (3745723) | 3745723..3746169 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| HWV51_RS18165 (3746184) | 3746184..3747125 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| HWV51_RS18170 (3747170) | 3747170..3747607 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| HWV51_RS18175 (3747604) | 3747604..3748476 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| HWV51_RS18180 (3748470) | 3748470..3749069 | - | 600 | WP_000965702.1 | glucose-1-phosphatase | - |
| HWV51_RS18185 (3749260) | 3749260..3750063 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| HWV51_RS18190 (3750097) | 3750097..3750993 | - | 897 | WP_001518956.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12404.39 Da Isoelectric Point: 9.5206
>T167131 WP_000558164.1 NZ_CP058671:3745415-3745726 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLKLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLKLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T167131 NZ_CP074698:c3481521-3481132 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT167131 WP_001259011.1 NZ_CP058671:3745723-3746169 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT167131 NZ_CP074698:c3481785-3481528 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|