Detailed information of TA system TA167130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 3743580..3744182
• Replicon: chromosome
• Accession: NZ_CP058671
• Organism: Salmonella enterica strain MS114

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: HWV51_RS18145
• Protein ID: WP_001159632.1
• Coordinates: 3743871..3744182 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HWV51_RS18140
• Protein ID: WP_000362050.1
• Coordinates: 3743580..3743870 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWV51_RS18125 (3741073)	3741073..3741975	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
HWV51_RS18130 (3741972)	3741972..3742607	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
HWV51_RS18135 (3742604)	3742604..3743533	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
HWV51_RS18140 (3743580)	3743580..3743870	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
HWV51_RS18145 (3743871)	3743871..3744182	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
HWV51_RS18150 (3744400)	3744400..3745329	+	930	WP_001127700.1	alpha/beta hydrolase	-
HWV51_RS18155 (3745415)	3745415..3745726	+	312	WP_000558164.1	type II toxin-antitoxin system HigB family toxin	-
HWV51_RS18160 (3745723)	3745723..3746169	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
HWV51_RS18165 (3746184)	3746184..3747125	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
HWV51_RS18170 (3747170)	3747170..3747607	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
HWV51_RS18175 (3747604)	3747604..3748476	-	873	WP_000921423.1	virulence factor BrkB family protein	-
HWV51_RS18180 (3748470)	3748470..3749069	-	600	WP_000965702.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T167130 WP_001159632.1 NZ_CP058671:c3744182-3743871 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T167130 NZ_CP074698:c2735595-2735413 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT167130 WP_000362050.1 NZ_CP058671:c3743870-3743580 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT167130 NZ_CP074698:c2735348-2734944 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATCGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAACGTAACTTTACCTAGCCGTTTAATTCGCAAGAT
TGATGATAATGTAGGTAAAGATAAAAGATTTAAAACTCGTTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31