Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 349765..350348 Replicon chromosome
Accession NZ_CP058669
Organism Hyphobacterium sp. CCMP332

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HXX25_RS01815 Protein ID WP_187166832.1
Coordinates 349765..350046 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXX25_RS01820 Protein ID WP_187167719.1
Coordinates 350058..350348 (+) Length 97 a.a.

Genomic Context

HXX25_RS01775HXX25_RS01780HXX25_RS01795HXX25_RS01800HXX25_RS01805HXX25_RS01810HXX25_RS01815HXX25_RS01820HXX25_RS01835HXX25_RS01785HXX25_RS01790HXX25_RS01825HXX25_RS01830HXX25_RS01840HXX25_RS01845
Location: 344775..345380 (606 bp)
Type: Others
Protein ID: WP_187166825.1
Location: 345444..345767 (324 bp)
Type: Others
Protein ID: WP_187166826.1
Location: 346887..347798 (912 bp)
Type: Others
Protein ID: WP_187166828.1
Location: 348164..348373 (210 bp)
Type: Others
Protein ID: WP_187166829.1
Location: 348485..348706 (222 bp)
Type: Others
Protein ID: WP_187166830.1
Location: 348820..349245 (426 bp)
Type: Others
Protein ID: WP_187166831.1
Location: 349765..350046 (282 bp)
Type: Toxin
Protein ID: WP_187166832.1
Location: 350058..350348 (291 bp)
Type: Antitoxin
Protein ID: WP_187167719.1
Location: 351942..352412 (471 bp)
Type: Others
Protein ID: WP_187166834.1
Location: 345827..346096 (270 bp)
Type: Others
Protein ID: WP_187167718.1
Location: 346408..346752 (345 bp)
Type: Others
Protein ID: WP_187166827.1
Location: 350345..350716 (372 bp)
Type: Others
Protein ID: WP_187166833.1
Location: 350730..351734 (1005 bp)
Type: Others
Protein ID: WP_187167720.1
Location: 352480..353874 (1395 bp)
Type: Others
Protein ID: WP_187166835.1
Location: 353871..354740 (870 bp)
Type: Others
Protein ID: WP_187166836.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HXX25_RS01775344775..345380+606WP_187166825.1hypothetical protein-
HXX25_RS01780345444..345767+324WP_187166826.1hypothetical protein-
HXX25_RS01785345827..346096-270WP_187167718.1DUF2282 domain-containing protein-
HXX25_RS01790346408..346752-345WP_187166827.1dihydroneopterin aldolase-
HXX25_RS01795346887..347798+912WP_187166828.1phenylalanine 4-monooxygenase-
HXX25_RS01800348164..348373+210WP_187166829.1cold-shock protein-
HXX25_RS01805348485..348706+222WP_187166830.1hypothetical protein-
HXX25_RS01810348820..349245+426WP_187166831.1hypothetical protein-
HXX25_RS01815349765..350046+282WP_187166832.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HXX25_RS01820350058..350348+291WP_187167719.1HigA family addiction module antidote proteinAntitoxin
HXX25_RS01825350345..350716-372WP_187166833.16-carboxytetrahydropterin synthase-
HXX25_RS01830350730..351734-1005WP_187167720.1calcium/sodium antiporter-
HXX25_RS01835351942..352412+471WP_187166834.1NUDIX domain-containing protein-
HXX25_RS01840352480..353874-1395WP_187166835.1YfcC family protein-
HXX25_RS01845353871..354740-870WP_187166836.1N-formylglutamate amidohydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(20-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10329.91 Da        Isoelectric Point: 10.6127

>T167104 WP_187166832.1 NZ_CP058669:349765-350046 [Hyphobacterium sp. CCMP332]
MIQSTRGKRAANALKGIYGKGFPGDLVKRTRAMLSALDAAVVLDDLRFPPGNHLEELKGDRAGQHSVRISRKWRICFVWT
ANGPANVEIVDYH

Download         Length: 282 bp

>T167104 NZ_CP074680:c2471629-2471453 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10741.60 Da        Isoelectric Point: 8.5161

>AT167104 WP_187167719.1 NZ_CP058669:350058-350348 [Hyphobacterium sp. CCMP332]
MSLLEDPMHPGEVLKELYLDPLDMGAIAFARRLGVPRTRIERLIKGTTGITPDTALRLARAFSTIPAYWMNLQTNYDMAI
ARKKVDVSWIEPLGAA

Download         Length: 291 bp

>AT167104 NZ_CP074680:c2471407-2470991 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References