Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 349765..350348 Replicon chromosome
Accession NZ_CP058669
Organism Hyphobacterium sp. CCMP332

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HXX25_RS01815 Protein ID WP_187166832.1
Coordinates 349765..350046 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXX25_RS01820 Protein ID WP_187167719.1
Coordinates 350058..350348 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXX25_RS01775 344775..345380 + 606 WP_187166825.1 hypothetical protein -
HXX25_RS01780 345444..345767 + 324 WP_187166826.1 hypothetical protein -
HXX25_RS01785 345827..346096 - 270 WP_187167718.1 DUF2282 domain-containing protein -
HXX25_RS01790 346408..346752 - 345 WP_187166827.1 dihydroneopterin aldolase -
HXX25_RS01795 346887..347798 + 912 WP_187166828.1 phenylalanine 4-monooxygenase -
HXX25_RS01800 348164..348373 + 210 WP_187166829.1 cold-shock protein -
HXX25_RS01805 348485..348706 + 222 WP_187166830.1 hypothetical protein -
HXX25_RS01810 348820..349245 + 426 WP_187166831.1 hypothetical protein -
HXX25_RS01815 349765..350046 + 282 WP_187166832.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXX25_RS01820 350058..350348 + 291 WP_187167719.1 HigA family addiction module antidote protein Antitoxin
HXX25_RS01825 350345..350716 - 372 WP_187166833.1 6-carboxytetrahydropterin synthase -
HXX25_RS01830 350730..351734 - 1005 WP_187167720.1 calcium/sodium antiporter -
HXX25_RS01835 351942..352412 + 471 WP_187166834.1 NUDIX domain-containing protein -
HXX25_RS01840 352480..353874 - 1395 WP_187166835.1 YfcC family protein -
HXX25_RS01845 353871..354740 - 870 WP_187166836.1 N-formylglutamate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(20-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10329.91 Da        Isoelectric Point: 10.6127

>T167104 WP_187166832.1 NZ_CP058669:349765-350046 [Hyphobacterium sp. CCMP332]
MIQSTRGKRAANALKGIYGKGFPGDLVKRTRAMLSALDAAVVLDDLRFPPGNHLEELKGDRAGQHSVRISRKWRICFVWT
ANGPANVEIVDYH

Download         Length: 282 bp

>T167104 NZ_CP074680:c2471629-2471453 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10741.60 Da        Isoelectric Point: 8.5161

>AT167104 WP_187167719.1 NZ_CP058669:350058-350348 [Hyphobacterium sp. CCMP332]
MSLLEDPMHPGEVLKELYLDPLDMGAIAFARRLGVPRTRIERLIKGTTGITPDTALRLARAFSTIPAYWMNLQTNYDMAI
ARKKVDVSWIEPLGAA

Download         Length: 291 bp

>AT167104 NZ_CP074680:c2471407-2470991 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References