Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1617620..1618246 Replicon chromosome
Accession NZ_CP058668
Organism Treponema sp. B152

Toxin (Protein)


Gene name higB Uniprot ID Q73NN6
Locus tag HYB91_RS07525 Protein ID WP_002677634.1
Coordinates 1617620..1617928 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HYB91_RS07530 Protein ID WP_253682324.1
Coordinates 1617938..1618246 (+) Length 103 a.a.

Genomic Context

HYB91_RS07500HYB91_RS07505HYB91_RS07520HYB91_RS07525HYB91_RS07530HYB91_RS07535HYB91_RS07540HYB91_RS07510HYB91_RS07515HYB91_RS07545HYB91_RS07550HYB91_RS07555
Location: 1613572..1613910 (339 bp)
Type: Others
Protein ID: WP_010696721.1
Location: 1613927..1614469 (543 bp)
Type: Others
Protein ID: WP_253719454.1
Location: 1616022..1617401 (1380 bp)
Type: Others
Protein ID: WP_253719457.1
Location: 1617620..1617928 (309 bp)
Type: Toxin
Protein ID: WP_002677634.1
Location: 1617938..1618246 (309 bp)
Type: Antitoxin
Protein ID: WP_253682324.1
Location: 1618380..1619051 (672 bp)
Type: Others
Protein ID: WP_253719458.1
Location: 1619140..1619556 (417 bp)
Type: Others
Protein ID: WP_253719459.1
Location: 1614477..1615304 (828 bp)
Type: Others
Protein ID: WP_253719455.1
Location: 1615285..1615905 (621 bp)
Type: Others
Protein ID: WP_253719456.1
Location: 1619699..1620328 (630 bp)
Type: Others
Protein ID: WP_253719460.1
Location: 1620384..1621613 (1230 bp)
Type: Others
Protein ID: WP_010696711.1
Location: 1621652..1622971 (1320 bp)
Type: Others
Protein ID: WP_002670665.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HYB91_RS07500 (HYB91_07465)1613572..1613910+339WP_010696721.1anti-sigma factor antagonist-
HYB91_RS07505 (HYB91_07470)1613927..1614469+543WP_253719454.1ATP-binding protein-
HYB91_RS07510 (HYB91_07475)1614477..1615304-828WP_253719455.1hypothetical protein-
HYB91_RS07515 (HYB91_07480)1615285..1615905-621WP_253719456.1hypothetical protein-
HYB91_RS07520 (HYB91_07485)1616022..1617401+1380WP_253719457.1tyrosine phenol-lyase-
HYB91_RS07525 (HYB91_07490)1617620..1617928+309WP_002677634.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HYB91_RS07530 (HYB91_07495)1617938..1618246+309WP_253682324.1NadS family proteinAntitoxin
HYB91_RS07535 (HYB91_07500)1618380..1619051+672WP_253719458.1TetR/AcrR family transcriptional regulator-
HYB91_RS07540 (HYB91_07505)1619140..1619556+417WP_253719459.1SRPBCC family protein-
HYB91_RS07545 (HYB91_07510)1619699..1620328-630WP_253719460.1adenylate kinase-
HYB91_RS07550 (HYB91_07515)1620384..1621613-1230WP_010696711.1cation:dicarboxylase symporter family transporter-
HYB91_RS07555 (HYB91_07520)1621652..1622971-1320WP_002670665.1leucine-rich repeat domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11736.96 Da        Isoelectric Point: 10.6864

>T167100 WP_002677634.1 NZ_CP058668:1617620-1617928 [Treponema sp. B152]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Download         Length: 309 bp

>T167100 NZ_CP074680:1856417-1856668 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11549.43 Da        Isoelectric Point: 9.6884

>AT167100 WP_253682324.1 NZ_CP058668:1617938-1618246 [Treponema sp. B152]
MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Download         Length: 309 bp

>AT167100 NZ_CP074680:1856665-1856919 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ73NN6

Antitoxin

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Source
ID
Structure
No matching records found

References