Detailed information of TA system TA167096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 763637..764150
• Replicon: chromosome
• Accession: NZ_CP058666
• Organism: Streptococcus agalactiae strain S9968

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: Q8DX49
• Locus tag: S9968_RS04250
• Protein ID: WP_000481712.1
• Coordinates: 763896..764150 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q8DX48
• Locus tag: S9968_RS04245
• Protein ID: WP_000387490.1
• Coordinates: 763637..763903 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
S9968_RS04210	759903..761135	+	1233	WP_000338840.1	replication initiation factor domain-containing protein	-
S9968_RS04215	761151..761528	+	378	WP_000287184.1	hypothetical protein	-
S9968_RS04220	761512..761727	+	216	WP_001897988.1	helix-turn-helix domain-containing protein	-
S9968_RS04225	761720..762073	+	354	WP_000571928.1	helix-turn-helix domain-containing protein	-
S9968_RS04230	762205..762477	+	273	WP_000072642.1	hypothetical protein	-
S9968_RS04235	762529..763011	+	483	WP_000383282.1	antirestriction protein ArdA	-
S9968_RS04240	763019..763492	+	474	WP_000560386.1	hypothetical protein	-
S9968_RS04245	763637..763903	+	267	WP_000387490.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
S9968_RS04250	763896..764150	+	255	WP_000481712.1	Txe/YoeB family addiction module toxin	Toxin
S9968_RS04255	764203..765156	+	954	WP_000565542.1	conjugal transfer protein	-
S9968_RS04260	765176..765442	+	267	WP_001055036.1	hypothetical protein	-
S9968_RS04265	765446..765856	+	411	WP_000390748.1	conjugal transfer protein	-
S9968_RS04270	765877..768378	+	2502	WP_000239405.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	748805..777345	28540

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10445.87 Da
• Isoelectric Point: 6.7282

>T167096 WP_000481712.1 NZ_CP058666:763896-764150 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T167096 NZ_CP074680:286905-287432 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10316.70 Da
• Isoelectric Point: 4.6742

>AT167096 WP_000387490.1 NZ_CP058666:763637-763903 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Nucleotide

• Length: 267 bp

>AT167096 NZ_CP074680:286632-286898 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A829IC12

Antitoxin

• AlphaFold DB: A0A829I9V6