Detailed information of TA system TA167042

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3866695..3866953
• Replicon: chromosome
• Accession: NZ_CP058656
• Organism: Escherichia coli strain WCHEC035125

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HZR25_RS18625
• Protein ID: WP_000935262.1
• Coordinates: 3866744..3866953 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3866695..3866752 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR25_RS18600	3861749..3862525	+	777	WP_166666977.1	fimbria/pilus outer membrane usher protein	-
HZR25_RS18605	3862541..3862762	+	222	Protein_3634	fimbria/pilus outer membrane usher protein	-
HZR25_RS18610	3863087..3864045	+	959	Protein_3635	fimbrial family protein	-
HZR25_RS18615	3864084..3864983	-	900	WP_001300855.1	transcriptional activator NhaR	-
HZR25_RS18620	3865049..3866215	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3866695..3866752	-	58	-	-	Antitoxin
HZR25_RS18625	3866744..3866953	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZR25_RS18630	3867057..3868187	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HZR25_RS18635	3868276..3870192	-	1917	WP_000516131.1	molecular chaperone DnaK	-
HZR25_RS18640	3870569..3870973	+	405	WP_000843559.1	DUF2541 family protein	-
HZR25_RS18645	3870999..3871712	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T167042 WP_000935262.1 NZ_CP058656:3866744-3866953 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T167042 NZ_CP074661:835975-836373 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT167042 NZ_CP058656:c3866752-3866695 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin