Detailed information of TA system TA167010

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3864909..3865167
• Replicon: chromosome
• Accession: NZ_CP058651
• Organism: Escherichia coli strain WCHEC035123

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HZR24_RS18625
• Protein ID: WP_000935262.1
• Coordinates: 3864958..3865167 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3864909..3864966 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR24_RS18600	3859963..3860739	+	777	WP_166666977.1	fimbria/pilus outer membrane usher protein	-
HZR24_RS18605	3860755..3860976	+	222	Protein_3634	fimbria/pilus outer membrane usher protein	-
HZR24_RS18610	3861301..3862259	+	959	Protein_3635	fimbrial family protein	-
HZR24_RS18615	3862298..3863197	-	900	WP_001300855.1	transcriptional activator NhaR	-
HZR24_RS18620	3863263..3864429	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3864909..3864966	-	58	-	-	Antitoxin
HZR24_RS18625	3864958..3865167	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZR24_RS18630	3865271..3866401	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HZR24_RS18635	3866490..3868406	-	1917	WP_000516131.1	molecular chaperone DnaK	-
HZR24_RS18640	3868783..3869187	+	405	WP_000843559.1	DUF2541 family protein	-
HZR24_RS18645	3869213..3869926	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T167010 WP_000935262.1 NZ_CP058651:3864958-3865167 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T167010 NZ_CP074584:3989552-3989923 [Enterobacter asburiae]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATCGATCTTTTTAATAATCGTGTTGAGGCGGCGGATGCCATTGA
TCGCACGGCGTCGCATAGAGCCATTAGCCTGATCACGTGGATGGAAGTCATGGTGGGTGCGCGCAAGCACGGACATGAAG
CAAAAACGGCGGCTGTGATGGGGGCTTTTGAGATTATTGATCTTTCTCGGGATATCGCAGAAAGAAGCGTTTTACTTCGC
GAGAAACATGGGATGAAACTGCCTGATGCCATTATTCTGGCTACTGCTCAGAGCAGAAGTTGCCCGTTAATCTCACGCAA
TACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAGCTGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT167010 NZ_CP058651:c3864966-3864909 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin