Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 670611..671119 | Replicon | plasmid pRZP2 |
| Accession | NZ_CP058639 | ||
| Organism | Rhodococcus sp. ZPP | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A6P1IBG8 |
| Locus tag | HYG77_RS34375 | Protein ID | WP_072948949.1 |
| Coordinates | 670859..671119 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | Q0RYC5 |
| Locus tag | HYG77_RS34370 | Protein ID | WP_005569061.1 |
| Coordinates | 670611..670862 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HYG77_RS34355 (HYG77_34305) | 667823..668536 | + | 714 | WP_208964050.1 | LppX_LprAFG lipoprotein | - |
| HYG77_RS34360 (HYG77_34310) | 668533..670107 | + | 1575 | WP_208964051.1 | MFS transporter | - |
| HYG77_RS34365 (HYG77_34315) | 670163..670564 | - | 402 | WP_244461539.1 | hypothetical protein | - |
| HYG77_RS34370 (HYG77_34320) | 670611..670862 | + | 252 | WP_005569061.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| HYG77_RS34375 (HYG77_34325) | 670859..671119 | + | 261 | WP_072948949.1 | Txe/YoeB family addiction module toxin | Toxin |
| HYG77_RS34380 (HYG77_34330) | 671937..673643 | - | 1707 | WP_208964052.1 | DEAD/DEAH box helicase family protein | - |
| HYG77_RS34390 (HYG77_34340) | 674376..675623 | + | 1248 | WP_208962286.1 | IS256 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..926330 | 926330 | |
| - | flank | IS/Tn | - | - | 674376..675623 | 1247 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10412.81 Da Isoelectric Point: 8.8670
>T166983 WP_072948949.1 NZ_CP058639:670859-671119 [Rhodococcus sp. ZPP]
MKLVWDESAWEDYVWWQAQDRKIVKRINTLLKDVERNGNDGIGKPEPLKHGFQGYWSRRITDEHRLVYKIVDDQIRIAAC
RYHYGH
MKLVWDESAWEDYVWWQAQDRKIVKRINTLLKDVERNGNDGIGKPEPLKHGFQGYWSRRITDEHRLVYKIVDDQIRIAAC
RYHYGH
Download Length: 261 bp
>T166983 NZ_CP074577:c178101-177952 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9358.50 Da Isoelectric Point: 4.5216
>AT166983 WP_005569061.1 NZ_CP058639:670611-670862 [Rhodococcus sp. ZPP]
MRTMTYSESRARYAEVLNAVVDDREEIVITRAGHEPVVMVSLDDYESLKETAYLLRSPENARRLLASIDRLESGGGTVRD
LAE
MRTMTYSESRARYAEVLNAVVDDREEIVITRAGHEPVVMVSLDDYESLKETAYLLRSPENARRLLASIDRLESGGGTVRD
LAE
Download Length: 252 bp
>AT166983 NZ_CP074577:178145-178206 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1IBG8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q0RYC5 |