Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 670611..671119 Replicon plasmid pRZP2
Accession NZ_CP058639
Organism Rhodococcus sp. ZPP

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6P1IBG8
Locus tag HYG77_RS34375 Protein ID WP_072948949.1
Coordinates 670859..671119 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q0RYC5
Locus tag HYG77_RS34370 Protein ID WP_005569061.1
Coordinates 670611..670862 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYG77_RS34355 (HYG77_34305) 667823..668536 + 714 WP_208964050.1 LppX_LprAFG lipoprotein -
HYG77_RS34360 (HYG77_34310) 668533..670107 + 1575 WP_208964051.1 MFS transporter -
HYG77_RS34365 (HYG77_34315) 670163..670564 - 402 WP_244461539.1 hypothetical protein -
HYG77_RS34370 (HYG77_34320) 670611..670862 + 252 WP_005569061.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HYG77_RS34375 (HYG77_34325) 670859..671119 + 261 WP_072948949.1 Txe/YoeB family addiction module toxin Toxin
HYG77_RS34380 (HYG77_34330) 671937..673643 - 1707 WP_208964052.1 DEAD/DEAH box helicase family protein -
HYG77_RS34390 (HYG77_34340) 674376..675623 + 1248 WP_208962286.1 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..926330 926330
- flank IS/Tn - - 674376..675623 1247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10412.81 Da        Isoelectric Point: 8.8670

>T166983 WP_072948949.1 NZ_CP058639:670859-671119 [Rhodococcus sp. ZPP]
MKLVWDESAWEDYVWWQAQDRKIVKRINTLLKDVERNGNDGIGKPEPLKHGFQGYWSRRITDEHRLVYKIVDDQIRIAAC
RYHYGH

Download         Length: 261 bp

>T166983 NZ_CP074577:c178101-177952 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9358.50 Da        Isoelectric Point: 4.5216

>AT166983 WP_005569061.1 NZ_CP058639:670611-670862 [Rhodococcus sp. ZPP]
MRTMTYSESRARYAEVLNAVVDDREEIVITRAGHEPVVMVSLDDYESLKETAYLLRSPENARRLLASIDRLESGGGTVRD
LAE

Download         Length: 252 bp

>AT166983 NZ_CP074577:178145-178206 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1IBG8

Antitoxin

Source ID Structure
AlphaFold DB Q0RYC5

References