166982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5354173..5354858 Replicon chromosome
Accession NZ_CP058638
Organism Rhodococcus sp. ZPP

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HYG77_RS24695 Protein ID WP_208960930.1
Coordinates 5354173..5354526 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HYG77_RS24700 Protein ID WP_230989920.1
Coordinates 5354541..5354858 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYG77_RS24690 (HYG77_24645) 5352756..5353835 + 1080 WP_109332205.1 redox-regulated ATPase YchF -
HYG77_RS24695 (HYG77_24650) 5354173..5354526 + 354 WP_208960930.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYG77_RS24700 (HYG77_24655) 5354541..5354858 + 318 WP_230989920.1 XRE family transcriptional regulator Antitoxin
HYG77_RS24705 (HYG77_24660) 5354941..5355855 + 915 WP_208960932.1 exodeoxyribonuclease III -
HYG77_RS24710 (HYG77_24665) 5355886..5356056 - 171 WP_204164790.1 hypothetical protein -
HYG77_RS24715 (HYG77_24670) 5356234..5357073 - 840 WP_109332201.1 GAF and ANTAR domain-containing protein -
HYG77_RS24720 (HYG77_24675) 5357255..5357479 + 225 WP_208960933.1 hypothetical protein -
HYG77_RS24725 (HYG77_24680) 5357404..5358270 - 867 WP_208960934.1 PE-PPE domain-containing protein -
HYG77_RS24730 (HYG77_24685) 5358351..5358755 - 405 WP_109332199.1 DUF1304 domain-containing protein -
HYG77_RS24735 (HYG77_24690) 5358752..5359216 - 465 WP_208960935.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13256.95 Da        Isoelectric Point: 4.6545

>T166982 WP_208960930.1 NZ_CP058638:5354173-5354526 [Rhodococcus sp. ZPP]
VFNVELLKEVEEWFIELASTDPEAAEHVAGAIDLLEATGPTLGRPVVDKVKASRFHSMKELRPPGTHIRILFIFDPHRDA
VLLVGGDKTGQWRAWYAENIPVADDRYQKRLDGDYDD

Download         Length: 354 bp

>T166982 NZ_CP074577:c174565-174278 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11639.12 Da        Isoelectric Point: 8.6044

>AT166982 WP_230989920.1 NZ_CP058638:5354541-5354858 [Rhodococcus sp. ZPP]
VARNWREVRAEAVDNGLIDPQRADNARKEMHEMVRAYRLADIRKAQGPRQADVAKALGVSQARVSKLERGDLQHTELGTL
ESYVAALGGRLRVVADFGDDSITLQ

Download         Length: 318 bp

>AT166982 NZ_CP074577:c174813-174562 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References