Detailed information of TA system TA166948

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2205775..2206033
• Replicon: chromosome
• Accession: NZ_CP058618
• Organism: Escherichia coli strain JS316

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HZF20_RS10660
• Protein ID: WP_000935262.1
• Coordinates: 2205824..2206033 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2205775..2205832 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZF20_RS10635	2200829..2201605	+	777	WP_166666977.1	fimbria/pilus outer membrane usher protein	-
HZF20_RS10640	2201780..2202154	+	375	WP_021521651.1	hypothetical protein	-
HZF20_RS10645	2202167..2203125	+	959	Protein_2081	fimbrial family protein	-
HZF20_RS10650	2203164..2204063	-	900	WP_001300855.1	transcriptional activator NhaR	-
HZF20_RS10655	2204129..2205295	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	2205775..2205832	-	58	-	-	Antitoxin
HZF20_RS10660	2205824..2206033	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
HZF20_RS10665	2206137..2207267	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HZF20_RS10670	2207356..2209272	-	1917	WP_000516131.1	molecular chaperone DnaK	-
HZF20_RS10675	2209649..2210053	+	405	WP_000843559.1	DUF2541 family protein	-
HZF20_RS10680	2210079..2210792	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T166948 WP_000935262.1 NZ_CP058618:2205824-2206033 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T166948 NZ_CP074570:c3733606-3733295 [Paraneptunicella aestuarii]
ATGATATTTATTGAAACGAGTCTGTTTACCAAGATGTTACCGGATTATCTCAATGATGAGGATTACCGGAACTTGCAATC
GTATTTATTGCAAAAGCCTGATGCAGGCGACATTGTCAAAGGTACTGGAGGAGTCCGGAAAGTTCGCTGGGCACTAGAAG
GAAAAGGTAAAAGTGGTGGTGTCCGTGCCATTTATTACTGGAAGAAATCTGAGTACGAAATTTGGATGTTAACCATTTAC
AGTAAATCTGAAAGAACAACGATTCCAAGCCATATATTGAAACAAATTGCAGAGGCGATAGACAATGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT166948 NZ_CP058618:c2205832-2205775 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin