Detailed information of TA system TA166935

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1039073..1039255
• Replicon: chromosome
• Accession: NZ_CP058615
• Organism: Staphylococcus aureus strain 110900

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HZR12_RS05405
• Protein ID: WP_001801861.1
• Coordinates: 1039160..1039255 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1039073..1039132 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR12_RS05365	1034073..1034267	-	195	Protein_1017	IS3 family transposase	-
HZR12_RS05370	1034536..1035531	-	996	WP_053017818.1	putative sulfate exporter family transporter	-
HZR12_RS05375	1035646..1036467	+	822	WP_000371597.1	LysR family transcriptional regulator	-
HZR12_RS05380	1036605..1037309	+	705	WP_048665789.1	helix-turn-helix domain-containing protein	-
HZR12_RS05385	1037228..1038157	+	930	WP_117206203.1	IS3 family transposase	-
HZR12_RS05390	1038385..1038588	+	204	Protein_1022	DUF1433 domain-containing protein	-
HZR12_RS05395	1038782..1038958	+	177	Protein_1023	transposase	-
HZR12_RS05400	1038936..1039037	-	102	WP_001791893.1	hypothetical protein	-
-	1039073..1039132	+	60	-	-	Antitoxin
HZR12_RS05405	1039160..1039255	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
HZR12_RS05410	1039458..1039601	+	144	WP_001549059.1	transposase	-
HZR12_RS05415	1040205..1040588	+	384	WP_000070812.1	hypothetical protein	-
HZR12_RS05420	1040599..1040775	+	177	WP_000375476.1	hypothetical protein	-
HZR12_RS05425	1040777..1040962	+	186	WP_000809857.1	hypothetical protein	-
HZR12_RS05430	1041076..1041717	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
HZR12_RS05435	1041935..1042486	-	552	WP_000414205.1	hypothetical protein	-
HZR12_RS05440	1042584..1042928	-	345	WP_000627551.1	DUF3969 family protein	-
HZR12_RS05445	1042969..1043595	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fusB	-	1008661..1076695	68034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T166935 WP_001801861.1 NZ_CP058615:c1039255-1039160 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T166935 NZ_CP074558:c4907693-4907409 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT166935 NZ_CP058615:1039073-1039132 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin