Detailed information of TA system TA166927

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 731104..731367
• Replicon: chromosome
• Accession: NZ_CP058615
• Organism: Staphylococcus aureus strain 110900

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HZR12_RS03625
• Protein ID: WP_001802298.1
• Coordinates: 731104..731208 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	731203..731367 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR12_RS03600	726488..727270	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
HZR12_RS03605	727338..728195	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
HZR12_RS03610	728900..728992	-	93	WP_001790138.1	hypothetical protein	-
HZR12_RS03615	729281..730417	+	1137	WP_000115562.1	SAP domain-containing protein	-
HZR12_RS03620	730460..730943	+	484	Protein_712	recombinase family protein	-
HZR12_RS03625	731104..731208	+	105	WP_001802298.1	hypothetical protein	Toxin
-	731203..731367	-	165	-	-	Antitoxin
HZR12_RS03630	731708..732799	-	1092	WP_000495671.1	lytic regulatory protein	-
HZR12_RS03635	733065..734045	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HZR12_RS03640	734047..734367	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HZR12_RS03645	734519..735184	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T166927 WP_001802298.1 NZ_CP058615:731104-731208 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T166927 NZ_CP074558:325718-326086 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT166927 NZ_CP058615:c731367-731203 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin