166926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 466423..466940 Replicon chromosome
Accession NZ_CP058615
Organism Staphylococcus aureus strain 110900

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HZR12_RS02240 Protein ID WP_000113262.1
Coordinates 466674..466940 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HZR12_RS02235 Protein ID WP_000584499.1
Coordinates 466423..466674 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR12_RS02200 461889..462101 + 213 Protein_437 cystatin-like fold lipoprotein -
HZR12_RS02205 462151..462825 - 675 WP_031919200.1 IS6-like element IS257 family transposase -
HZR12_RS02210 463593..464150 + 558 WP_048665604.1 hypothetical protein -
HZR12_RS02215 464634..465308 - 675 WP_001105987.1 IS6-like element IS257 family transposase -
HZR12_RS02220 465356..465532 + 177 Protein_441 cystatin-like fold lipoprotein -
HZR12_RS02225 465551..466150 + 600 WP_000162813.1 DsbA family protein -
HZR12_RS02230 466157..466258 + 102 WP_001791744.1 hypothetical protein -
HZR12_RS02235 466423..466674 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZR12_RS02240 466674..466940 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HZR12_RS02245 466975..467046 + 72 Protein_446 hypothetical protein -
HZR12_RS02250 467235..468785 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HZR12_RS02255 468971..469438 + 468 WP_000153344.1 SRPBCC domain-containing protein -
HZR12_RS02260 469522..469704 + 183 WP_000230294.1 hypothetical protein -
HZR12_RS02265 469921..470745 + 825 WP_000572040.1 formate/nitrite transporter family protein -
HZR12_RS02270 470978..471514 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T166926 WP_000113262.1 NZ_CP058615:466674-466940 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T166926 NZ_CP074555:c6116-5811 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT166926 WP_000584499.1 NZ_CP058615:466423-466674 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT166926 NZ_CP074555:c6336-6118 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References