Detailed information of TA system TA166924

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 438122..438306
• Replicon: chromosome
• Accession: NZ_CP058615
• Organism: Staphylococcus aureus strain 110900

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: HZR12_RS02085
• Protein ID: WP_000482650.1
• Coordinates: 438122..438229 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	438246..438306 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR12_RS02060	433485..433958	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
HZR12_RS02065	434081..435292	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HZR12_RS02070	435474..436133	-	660	WP_000831298.1	membrane protein	-
HZR12_RS02075	436193..437335	-	1143	WP_001176863.1	glycerate kinase	-
HZR12_RS02080	437603..437989	+	387	WP_000779358.1	flippase GtxA	-
HZR12_RS02085	438122..438229	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	438246..438306	-	61	-	-	Antitoxin
HZR12_RS02090	438857..440620	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
HZR12_RS02095	440645..442378	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
HZR12_RS02100	442609..442776	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T166924 WP_000482650.1 NZ_CP058615:438122-438229 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T166924 NZ_CP074553:c5365441-5365058 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT166924 NZ_CP058615:c438306-438246 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin