Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2276396..2276810 Replicon chromosome
Accession NZ_CP058613
Organism Staphylococcus aureus strain 128254

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HZR13_RS11470 Protein ID WP_048665700.1
Coordinates 2276559..2276810 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HZR13_RS11465 Protein ID WP_000028424.1
Coordinates 2276396..2276569 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR13_RS11420 2272477..2273751 - 1275 WP_048665702.1 PBSX family phage terminase large subunit -
HZR13_RS11425 2273738..2274178 - 441 WP_001003271.1 terminase small subunit -
HZR13_RS11430 2274364..2274783 - 420 WP_000058632.1 transcriptional regulator -
HZR13_RS11435 2274798..2274944 - 147 WP_000989998.1 hypothetical protein -
HZR13_RS11440 2274945..2275160 - 216 WP_048665701.1 hypothetical protein -
HZR13_RS11445 2275153..2275388 - 236 Protein_2227 hypothetical protein -
HZR13_RS11450 2275413..2275649 - 237 WP_000195831.1 DUF1381 domain-containing protein -
HZR13_RS11455 2275686..2276219 - 534 WP_031807824.1 dUTPase -
HZR13_RS11460 2276234..2276395 - 162 WP_000889682.1 hypothetical protein -
HZR13_RS11465 2276396..2276569 - 174 WP_000028424.1 hypothetical protein Antitoxin
HZR13_RS11470 2276559..2276810 - 252 WP_048665700.1 DUF1024 family protein Toxin
HZR13_RS11475 2276905..2277120 - 216 WP_048665717.1 hypothetical protein -
HZR13_RS11480 2277115..2277348 - 234 Protein_2234 hypothetical protein -
HZR13_RS11485 2277354..2277815 - 462 WP_048665699.1 hypothetical protein -
HZR13_RS11490 2277812..2278006 - 195 WP_048665698.1 hypothetical protein -
HZR13_RS11495 2278003..2278407 - 405 WP_000695764.1 hypothetical protein -
HZR13_RS11500 2278421..2278669 - 249 WP_000178883.1 phi PVL orf 51-like protein -
HZR13_RS11505 2278678..2278878 - 201 WP_000235323.1 hypothetical protein -
HZR13_RS11510 2278881..2279138 - 258 WP_000022739.1 DUF3310 domain-containing protein -
HZR13_RS11515 2279138..2279509 - 372 WP_000241093.1 hypothetical protein -
HZR13_RS11520 2279510..2279695 - 186 WP_029625657.1 DUF3113 family protein -
HZR13_RS11525 2279700..2280104 - 405 WP_000049789.1 DUF1064 domain-containing protein -
HZR13_RS11530 2280115..2280336 - 222 WP_001123695.1 DUF3269 family protein -
HZR13_RS11535 2280349..2280507 - 159 WP_031942166.1 hypothetical protein -
HZR13_RS11540 2280504..2281289 - 786 WP_031942165.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2251193..2290505 39312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9389.28 Da        Isoelectric Point: 3.8567

>T166922 WP_048665700.1 NZ_CP058613:c2276810-2276559 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T166922 NZ_CP074553:c4881256-4880972 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT166922 WP_000028424.1 NZ_CP058613:c2276569-2276396 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT166922 NZ_CP074553:c4881488-4881246 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References