Detailed information of TA system TA166919

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1861416..1861598
• Replicon: chromosome
• Accession: NZ_CP058613
• Organism: Staphylococcus aureus strain 128254

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HZR13_RS09120
• Protein ID: WP_001801861.1
• Coordinates: 1861416..1861511 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1861539..1861598 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR13_RS09080	1857076..1857702	+	627	WP_000669046.1	hypothetical protein	-
HZR13_RS09085	1857743..1858087	+	345	WP_000627551.1	DUF3969 family protein	-
HZR13_RS09090	1858185..1858736	+	552	WP_000414205.1	hypothetical protein	-
HZR13_RS09095	1858954..1859595	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
HZR13_RS09100	1859709..1859894	-	186	WP_000809857.1	hypothetical protein	-
HZR13_RS09105	1859896..1860072	-	177	WP_000375476.1	hypothetical protein	-
HZR13_RS09110	1860083..1860466	-	384	WP_000070812.1	hypothetical protein	-
HZR13_RS09115	1861070..1861213	-	144	WP_001549059.1	transposase	-
HZR13_RS09120	1861416..1861511	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1861539..1861598	-	60	-	-	Antitoxin
HZR13_RS09125	1861634..1861735	+	102	WP_001791893.1	hypothetical protein	-
HZR13_RS09130	1861713..1861889	-	177	Protein_1804	transposase	-
HZR13_RS09135	1862083..1862286	-	204	Protein_1805	DUF1433 domain-containing protein	-
HZR13_RS09140	1862514..1863443	-	930	WP_117206203.1	IS3 family transposase	-
HZR13_RS09145	1863362..1864066	-	705	WP_048665789.1	helix-turn-helix domain-containing protein	-
HZR13_RS09150	1864204..1865025	-	822	WP_000371597.1	LysR family transcriptional regulator	-
HZR13_RS09155	1865140..1866135	+	996	WP_053017818.1	putative sulfate exporter family transporter	-
HZR13_RS09160	1866404..1866598	+	195	Protein_1810	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fusB	-	1854516..1897376	42860

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T166919 WP_001801861.1 NZ_CP058613:1861416-1861511 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T166919 NZ_CP074553:c2827183-2825861 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT166919 NZ_CP058613:c1861598-1861539 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin