Detailed information of TA system TA166912

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 701419..701698
• Replicon: chromosome
• Accession: NZ_CP058613
• Organism: Staphylococcus aureus strain 128254

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HZR13_RS03450
• Protein ID: WP_001802298.1
• Coordinates: 701419..701523 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	701519..701698 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR13_RS03425	696803..697585	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
HZR13_RS03430	697653..698510	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
HZR13_RS03435	699215..699307	-	93	WP_001790138.1	hypothetical protein	-
HZR13_RS03440	699596..700732	+	1137	WP_000115562.1	SAP domain-containing protein	-
HZR13_RS03445	700775..701258	+	484	Protein_677	recombinase family protein	-
HZR13_RS03450	701419..701523	+	105	WP_001802298.1	hypothetical protein	Toxin
-	701519..701698	-	180	-	-	Antitoxin
HZR13_RS03455	702023..703114	-	1092	WP_000495671.1	lytic regulatory protein	-
HZR13_RS03460	703380..704360	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HZR13_RS03465	704362..704682	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HZR13_RS03470	704834..705499	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T166912 WP_001802298.1 NZ_CP058613:701419-701523 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T166912 NZ_CP074545:4132974-4133192 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin

Nucleotide

• Length: 180 bp

>AT166912 NZ_CP058613:c701698-701519 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin