Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 436741..437258 Replicon chromosome
Accession NZ_CP058613
Organism Staphylococcus aureus strain 128254

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HZR13_RS02070 Protein ID WP_000113262.1
Coordinates 436992..437258 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HZR13_RS02065 Protein ID WP_000584499.1
Coordinates 436741..436992 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZR13_RS02030 432207..432419 + 213 Protein_403 cystatin-like fold lipoprotein -
HZR13_RS02035 432469..433143 - 675 WP_031919200.1 IS6-like element IS257 family transposase -
HZR13_RS02040 433911..434468 + 558 WP_048665604.1 hypothetical protein -
HZR13_RS02045 434952..435626 - 675 WP_001105987.1 IS6-like element IS257 family transposase -
HZR13_RS02050 435674..435850 + 177 Protein_407 cystatin-like fold lipoprotein -
HZR13_RS02055 435869..436468 + 600 WP_000162813.1 DsbA family protein -
HZR13_RS02060 436475..436576 + 102 WP_001791744.1 hypothetical protein -
HZR13_RS02065 436741..436992 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZR13_RS02070 436992..437258 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HZR13_RS02075 437293..437364 + 72 Protein_412 hypothetical protein -
HZR13_RS02080 437553..439103 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HZR13_RS02085 439289..439756 + 468 WP_000153344.1 SRPBCC domain-containing protein -
HZR13_RS02090 439840..440022 + 183 WP_000230294.1 hypothetical protein -
HZR13_RS02095 440239..441063 + 825 WP_000572040.1 formate/nitrite transporter family protein -
HZR13_RS02100 441296..441832 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T166910 WP_000113262.1 NZ_CP058613:436992-437258 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T166910 NZ_CP074545:2081206-2081236 [Klebsiella aerogenes]
CGAATACAGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT166910 WP_000584499.1 NZ_CP058613:436741-436992 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT166910 NZ_CP074545:c2081244-2081206 [Klebsiella aerogenes]
TAATAGATAAAAAGAGACCGAACACGATTCCTGTATTCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References