Detailed information of TA system TA166908

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 408440..408624
• Replicon: chromosome
• Accession: NZ_CP058613
• Organism: Staphylococcus aureus strain 128254

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: HZR13_RS01915
• Protein ID: WP_000482650.1
• Coordinates: 408440..408547 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	408564..408624 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZR13_RS01890	403803..404276	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
HZR13_RS01895	404399..405610	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
HZR13_RS01900	405792..406451	-	660	WP_000831298.1	membrane protein	-
HZR13_RS01905	406511..407653	-	1143	WP_001176863.1	glycerate kinase	-
HZR13_RS01910	407921..408307	+	387	WP_000779358.1	flippase GtxA	-
HZR13_RS01915	408440..408547	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	408564..408624	-	61	-	-	Antitoxin
HZR13_RS01920	409175..410938	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
HZR13_RS01925	410963..412696	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
HZR13_RS01930	412927..413094	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T166908 WP_000482650.1 NZ_CP058613:408440-408547 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T166908 NZ_CP074545:c1178590-1178261 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT166908 NZ_CP058613:c408624-408564 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin