Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3913773..3914423 Replicon chromosome
Accession NZ_CP058574
Organism Escherichia coli strain EC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HYH05_RS19005 Protein ID WP_000263532.1
Coordinates 3914082..3914423 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U9YXQ7
Locus tag HYH05_RS19000 Protein ID WP_000212552.1
Coordinates 3913773..3914072 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH05_RS18975 3909221..3909532 - 312 WP_000415004.1 hypothetical protein -
HYH05_RS18980 3909537..3909929 - 393 WP_000285322.1 flagellar export chaperone FliS -
HYH05_RS18985 3909952..3911268 - 1317 WP_000609678.1 flagellar filament capping protein FliD -
HYH05_RS18990 3911473..3912387 - 915 WP_000949083.1 lateral flagellin LafA -
HYH05_RS18995 3912873..3913715 + 843 WP_000022366.1 winged helix-turn-helix domain-containing protein -
HYH05_RS19000 3913773..3914072 - 300 WP_000212552.1 helix-turn-helix transcriptional regulator Antitoxin
HYH05_RS19005 3914082..3914423 - 342 WP_000263532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYH05_RS19010 3914499..3915476 - 978 WP_001195938.1 hypothetical protein -
HYH05_RS19015 3915493..3916422 - 930 WP_001266799.1 flagellar hook-associated protein FlgL -
HYH05_RS19020 3916437..3917813 - 1377 WP_000367245.1 flagellar hook-associated protein FlgK -
HYH05_RS19025 3917989..3918288 - 300 WP_000867281.1 rod-binding protein -
HYH05_RS19030 3918288..3919388 - 1101 WP_001181876.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.86 Da        Isoelectric Point: 6.4677

>T166855 WP_000263532.1 NZ_CP058574:c3914423-3914082 [Escherichia coli]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRKHLKK

Download         Length: 342 bp

>T166855 NZ_CP074528:2010311-2010413 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11004.86 Da        Isoelectric Point: 9.7665

>AT166855 WP_000212552.1 NZ_CP058574:c3914072-3913773 [Escherichia coli]
MATLKELMAKQSPESQVRIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRIAFQI

Download         Length: 300 bp

>AT166855 NZ_CP074528:c2010420-2010275 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U9YXQ7

References