Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 2648120..2648747 | Replicon | chromosome |
| Accession | NZ_CP058571 | ||
| Organism | Escherichia coli strain EC2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2A3VZJ4 |
| Locus tag | HX136_RS12995 | Protein ID | WP_001624509.1 |
| Coordinates | 2648120..2648449 (+) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HX136_RS13000 | Protein ID | WP_001624508.1 |
| Coordinates | 2648439..2648747 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HX136_RS12945 | 2643619..2643861 | - | 243 | WP_001624519.1 | hypothetical protein | - |
| HX136_RS12950 | 2643854..2644054 | - | 201 | WP_000994506.1 | protein ninH | - |
| HX136_RS12955 | 2644051..2644413 | - | 363 | WP_021565206.1 | RusA family crossover junction endodeoxyribonuclease | - |
| HX136_RS12960 | 2644410..2644700 | - | 291 | WP_024194163.1 | DUF1364 domain-containing protein | - |
| HX136_RS12965 | 2644724..2644915 | - | 192 | WP_001254269.1 | NinE family protein | - |
| HX136_RS12970 | 2644912..2645322 | - | 411 | WP_001076830.1 | recombination protein NinB | - |
| HX136_RS12975 | 2645377..2646045 | - | 669 | WP_001624513.1 | ORF6N domain-containing protein | - |
| HX136_RS12980 | 2646390..2646764 | + | 375 | WP_001624512.1 | DUF805 domain-containing protein | - |
| HX136_RS12985 | 2646784..2647455 | - | 672 | WP_001624511.1 | hypothetical protein | - |
| HX136_RS12990 | 2647467..2647891 | - | 425 | Protein_2552 | hypothetical protein | - |
| HX136_RS12995 | 2648120..2648449 | + | 330 | WP_001624509.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HX136_RS13000 | 2648439..2648747 | + | 309 | WP_001624508.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HX136_RS13005 | 2648802..2649047 | - | 246 | WP_001624507.1 | hypothetical protein | - |
| HX136_RS13010 | 2649046..2649720 | + | 675 | WP_032144013.1 | DUF4145 domain-containing protein | - |
| HX136_RS13015 | 2649753..2650184 | - | 432 | WP_000196185.1 | DUF977 family protein | - |
| HX136_RS13020 | 2650200..2650970 | - | 771 | WP_032182512.1 | DUF1627 domain-containing protein | - |
| HX136_RS13025 | 2650996..2651736 | - | 741 | WP_021571292.1 | ATP-binding protein | - |
| HX136_RS13030 | 2651743..2652837 | - | 1095 | WP_179231406.1 | DNA-binding protein | - |
| HX136_RS13035 | 2653000..2653296 | - | 297 | WP_000084293.1 | hypothetical protein | - |
| HX136_RS13040 | 2653325..2653684 | + | 360 | WP_001005964.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2594260..2660675 | 66415 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12835.93 Da Isoelectric Point: 9.9761
>T166816 WP_001624509.1 NZ_CP058571:2648120-2648449 [Escherichia coli]
MNYTIEYYSEEVRLEVDQLPLSMRVRYKHLIERMKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIML
HSFIKKTQKTPPAERKKAEARMKEVKHDW
MNYTIEYYSEEVRLEVDQLPLSMRVRYKHLIERMKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIML
HSFIKKTQKTPPAERKKAEARMKEVKHDW
Download Length: 330 bp
>T166816 NZ_CP074448:c3714554-3714144 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11173.88 Da Isoelectric Point: 8.5840
>AT166816 WP_001624508.1 NZ_CP058571:2648439-2648747 [Escherichia coli]
MTGKRITPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV
MTGKRITPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT166816 NZ_CP074448:c3714801-3714535 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|