Detailed information of TA system TA166810

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2338940..2339311
• Replicon: chromosome
• Accession: NZ_CP058571
• Organism: Escherichia coli strain EC2

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: HX136_RS11495
• Protein ID: WP_001443846.1
• Coordinates: 2339162..2339311 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2338940..2339118 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HX136_RS11470	2334895..2336268	+	1374	WP_179231386.1	ATP-dependent RNA helicase DbpA	-
HX136_RS11475	2336397..2337332	-	936	WP_001614527.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
HX136_RS11480	2337384..2338619	-	1236	WP_000040839.1	site-specific integrase	-
HX136_RS11485	2338621..2338836	-	216	WP_000079604.1	excisionase XisR	-
HX136_RS11490	2338936..2339124	-	189	WP_001302840.1	DUF1187 family protein	-
-	2338940..2339118	+	179	NuclAT_0	-	Antitoxin
-	2338940..2339118	+	179	NuclAT_0	-	Antitoxin
-	2338940..2339118	+	179	NuclAT_0	-	Antitoxin
-	2338940..2339118	+	179	NuclAT_0	-	Antitoxin
HX136_RS11495	2339162..2339311	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
HX136_RS11500	2339367..2340176	-	810	WP_000166313.1	recombination protein RecT	-
HX136_RS11505	2340169..2342769	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
HX136_RS11510	2342871..2343146	-	276	WP_000632297.1	protein RacC	-
HX136_RS11515	2343221..2343391	-	171	WP_001352098.1	conserved protein, Rac prophage	-
HX136_RS11520	2343391..2343612	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2337384..2386881	49497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T166810 WP_001443846.1 NZ_CP058571:c2339311-2339162 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T166810 NZ_CP074448:1048721-1048824 [Enterobacter asburiae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 179 bp

>AT166810 NZ_CP058571:2338940-2339118 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin