Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1724385..1724971 Replicon chromosome
Accession NZ_CP058548
Organism Klebsiella pneumoniae strain S165-1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HXT63_RS08730 Protein ID WP_002920800.1
Coordinates 1724385..1724753 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HXT63_RS08735 Protein ID WP_004174006.1
Coordinates 1724750..1724971 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT63_RS08710 (1719888) 1719888..1720958 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
HXT63_RS08715 (1720960) 1720960..1721805 - 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HXT63_RS08720 (1721802) 1721802..1722689 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HXT63_RS08725 (1722796) 1722796..1724112 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HXT63_RS08730 (1724385) 1724385..1724753 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HXT63_RS08735 (1724750) 1724750..1724971 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HXT63_RS08740 (1725135) 1725135..1725848 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HXT63_RS08745 (1725850) 1725850..1726617 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HXT63_RS08750 (1726614) 1726614..1727891 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HXT63_RS08755 (1727888) 1727888..1728814 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1719151..1727891 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T166784 WP_002920800.1 NZ_CP058548:c1724753-1724385 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T166784 NZ_CP074437:2214577-2214987 [Klebsiella sp. A52]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTAATCGACTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAGCCGG
CGCACGACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT166784 WP_004174006.1 NZ_CP058548:c1724971-1724750 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT166784 NZ_CP074437:2214330-2214596 [Klebsiella sp. A52]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCTGATGCGCAACTTCAACGGATGATAAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References