Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 123241..123968 | Replicon | plasmid pS161-2.2 |
Accession | NZ_CP058546 | ||
Organism | Klebsiella pneumoniae strain S161-2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7W3D9W1 |
Locus tag | HYH18_RS27455 | Protein ID | WP_011251285.1 |
Coordinates | 123241..123552 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | HYH18_RS27460 | Protein ID | WP_011251286.1 |
Coordinates | 123549..123968 (+) | Length | 140 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HYH18_RS27420 | 118410..118508 | - | 99 | WP_004118688.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
HYH18_RS27425 | 118656..119647 | + | 992 | Protein_134 | IS3 family transposase | - |
HYH18_RS27430 | 119679..120647 | + | 969 | WP_194433525.1 | IS5 family transposase | - |
HYH18_RS27435 | 120705..121754 | - | 1050 | Protein_136 | IS66 family transposase | - |
HYH18_RS27440 | 121803..122150 | - | 348 | WP_004114612.1 | IS66 family insertion sequence element accessory protein TnpB | - |
HYH18_RS27445 | 122147..122485 | - | 339 | WP_023288266.1 | transposase | - |
HYH18_RS27450 | 122599..123036 | + | 438 | Protein_139 | DDE-type integrase/transposase/recombinase | - |
HYH18_RS27455 | 123241..123552 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
HYH18_RS27460 | 123549..123968 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
HYH18_RS27465 | 124115..125083 | + | 969 | WP_194433524.1 | IS5 family transposase | - |
HYH18_RS27470 | 125337..126125 | - | 789 | WP_114263119.1 | hypothetical protein | - |
HYH18_RS27475 | 126125..126421 | - | 297 | WP_227662480.1 | conjugative transfer protein MobI(A/C) | - |
HYH18_RS27480 | 127182..127817 | + | 636 | WP_227662472.1 | hypothetical protein | - |
HYH18_RS27485 | 128130..128654 | + | 525 | WP_071444207.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aph(3')-Ia / mph(A) / sul1 / blaDHA-1 / qnrB4 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr | - | 1..178411 | 178411 | |
- | inside | IScluster/Tn | - | - | 118629..143865 | 25236 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T166772 WP_011251285.1 NZ_CP058546:123241-123552 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T166772 NZ_CP074428:c4031797-4031489 [Salmonella sp. SJTUF14523]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT166772 WP_011251286.1 NZ_CP058546:123549-123968 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT166772 NZ_CP074428:c4032039-4031800 [Salmonella sp. SJTUF14523]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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