Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1001583..1002229 Replicon chromosome
Accession NZ_CP058544
Organism Klebsiella pneumoniae strain S161-2

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag HYH18_RS04700 Protein ID WP_004188313.1
Coordinates 1001583..1001930 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag HYH18_RS04705 Protein ID WP_004174017.1
Coordinates 1001930..1002229 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH18_RS04690 997509..998942 + 1434 WP_094310019.1 glycogen synthase GlgA -
HYH18_RS04695 998960..1001407 + 2448 WP_002920561.1 glycogen phosphorylase -
HYH18_RS04700 1001583..1001930 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYH18_RS04705 1001930..1002229 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
HYH18_RS04710 1002292..1003800 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HYH18_RS04715 1004005..1004334 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HYH18_RS04720 1004385..1005215 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HYH18_RS04725 1005265..1006023 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T166755 WP_004188313.1 NZ_CP058544:1001583-1001930 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T166755 NZ_CP074425:c4488680-4488369 [Salmonella sp. SJTUF15034]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT166755 WP_004174017.1 NZ_CP058544:1001930-1002229 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT166755 NZ_CP074425:c4488368-4488078 [Salmonella sp. SJTUF15034]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References