Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2775562..2776215 Replicon chromosome
Accession NZ_CP058409
Organism Trichlorobacter lovleyi strain IAE

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FY034_RS12765 Protein ID WP_265551123.1
Coordinates 2775868..2776215 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FY034_RS12760 Protein ID WP_265551121.1
Coordinates 2775562..2775864 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY034_RS12730 (FY034_12745) 2771070..2771261 - 192 WP_265551115.1 hypothetical protein -
FY034_RS12735 (FY034_12750) 2771455..2773032 - 1578 WP_265555270.1 peptide chain release factor 3 -
FY034_RS12740 (FY034_12755) 2773104..2773550 - 447 WP_265551117.1 DoxX family protein -
FY034_RS12750 (FY034_12765) 2773771..2774367 + 597 WP_265555272.1 dephospho-CoA kinase -
FY034_RS12755 (FY034_12770) 2774364..2775545 + 1182 WP_265551119.1 THUMP domain-containing protein -
FY034_RS12760 (FY034_12775) 2775562..2775864 - 303 WP_265551121.1 helix-turn-helix transcriptional regulator Antitoxin
FY034_RS12765 (FY034_12780) 2775868..2776215 - 348 WP_265551123.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY034_RS12770 (FY034_12785) 2776327..2776695 - 369 WP_265551125.1 DUF1016 N-terminal domain-containing protein -
FY034_RS12775 (FY034_12790) 2777129..2777818 - 690 WP_265551127.1 Abi-alpha family protein -
FY034_RS12780 (FY034_12795) 2777973..2779310 - 1338 WP_265551129.1 sigma-54 dependent transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13314.29 Da        Isoelectric Point: 5.1873

>T166741 WP_265551123.1 NZ_CP058409:c2776215-2775868 [Trichlorobacter lovleyi]
VLWKIVTVEYFDDWFLGLDASEQQDVLAAIFVLEQYGPTLGRPHVDSLKGTDKVKNLKELRVQHKGKPYRVFFAFDPLRQ
AVMLCGGDKTGNKQFYESMVPVAEREFLNYLQELE

Download         Length: 348 bp

>T166741 NZ_CP074425:200452-200937 [Salmonella sp. SJTUF15034]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10959.62 Da        Isoelectric Point: 6.7273

>AT166741 WP_265551121.1 NZ_CP058409:c2775864-2775562 [Trichlorobacter lovleyi]
MAKQLSELIKKVDPTVVAAARTQADQEIFELRLAQLRQTVEMSQHDLAEALGISQPSVANLEKRGHEVKISSLKRYVEAL
GGKLSLDVELADGRHIGITV

Download         Length: 303 bp

>AT166741 NZ_CP074425:200177-200464 [Salmonella sp. SJTUF15034]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References