Detailed information of TA system TA166741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2775562..2776215
• Replicon: chromosome
• Accession: NZ_CP058409
• Organism: Trichlorobacter lovleyi strain IAE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FY034_RS12765
• Protein ID: WP_265551123.1
• Coordinates: 2775868..2776215 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FY034_RS12760
• Protein ID: WP_265551121.1
• Coordinates: 2775562..2775864 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY034_RS12730 (FY034_12745)	2771070..2771261	-	192	WP_265551115.1	hypothetical protein	-
FY034_RS12735 (FY034_12750)	2771455..2773032	-	1578	WP_265555270.1	peptide chain release factor 3	-
FY034_RS12740 (FY034_12755)	2773104..2773550	-	447	WP_265551117.1	DoxX family protein	-
FY034_RS12750 (FY034_12765)	2773771..2774367	+	597	WP_265555272.1	dephospho-CoA kinase	-
FY034_RS12755 (FY034_12770)	2774364..2775545	+	1182	WP_265551119.1	THUMP domain-containing protein	-
FY034_RS12760 (FY034_12775)	2775562..2775864	-	303	WP_265551121.1	helix-turn-helix transcriptional regulator	Antitoxin
FY034_RS12765 (FY034_12780)	2775868..2776215	-	348	WP_265551123.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY034_RS12770 (FY034_12785)	2776327..2776695	-	369	WP_265551125.1	DUF1016 N-terminal domain-containing protein	-
FY034_RS12775 (FY034_12790)	2777129..2777818	-	690	WP_265551127.1	Abi-alpha family protein	-
FY034_RS12780 (FY034_12795)	2777973..2779310	-	1338	WP_265551129.1	sigma-54 dependent transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13314.29 Da
• Isoelectric Point: 5.1873

>T166741 WP_265551123.1 NZ_CP058409:c2776215-2775868 [Trichlorobacter lovleyi]
VLWKIVTVEYFDDWFLGLDASEQQDVLAAIFVLEQYGPTLGRPHVDSLKGTDKVKNLKELRVQHKGKPYRVFFAFDPLRQ
AVMLCGGDKTGNKQFYESMVPVAEREFLNYLQELE

Nucleotide

• Length: 348 bp

>T166741 NZ_CP074425:200452-200937 [Salmonella sp. SJTUF15034]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10959.62 Da
• Isoelectric Point: 6.7273

>AT166741 WP_265551121.1 NZ_CP058409:c2775864-2775562 [Trichlorobacter lovleyi]
MAKQLSELIKKVDPTVVAAARTQADQEIFELRLAQLRQTVEMSQHDLAEALGISQPSVANLEKRGHEVKISSLKRYVEAL
GGKLSLDVELADGRHIGITV

Nucleotide

• Length: 303 bp

>AT166741 NZ_CP074425:200177-200464 [Salmonella sp. SJTUF15034]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA