166676

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1762342..1762844 Replicon chromosome
Accession NZ_CP058355
Organism Escherichia coli strain AMSCJX03

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HXS77_RS08305 Protein ID WP_000767829.1
Coordinates 1762590..1762844 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HXS77_RS08300 Protein ID WP_001259255.1
Coordinates 1762342..1762593 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS77_RS08275 1757521..1758588 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HXS77_RS08280 1758588..1759658 - 1071 WP_178887394.1 histidinol-phosphate transaminase -
HXS77_RS08285 1759655..1760959 - 1305 WP_029399146.1 histidinol dehydrogenase -
HXS77_RS08290 1760965..1761864 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HXS77_RS08295 1762010..1762060 - 51 WP_001364200.1 his operon leader peptide -
HXS77_RS08300 1762342..1762593 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HXS77_RS08305 1762590..1762844 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HXS77_RS08310 1762927..1763751 + 825 WP_029399144.1 SDR family oxidoreductase -
HXS77_RS08315 1763797..1764726 + 930 WP_000803351.1 LysR family transcriptional regulator -
HXS77_RS08320 1764941..1765003 + 63 WP_010723108.1 membrane protein YoeI -
HXS77_RS08325 1764993..1766351 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HXS77_RS08330 1766530..1767588 + 1059 WP_032352489.1 transport protein YeeE -
HXS77_RS08335 1767602..1767829 + 228 WP_097430815.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T166676 WP_000767829.1 NZ_CP058355:1762590-1762844 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T166676 NZ_CP074371:3912462-3912728 [Nocardia tengchongensis]
ATGACCTATGCGGTCGAATTCACCCCAACCGCACGGCGCGAGATCGCCAAGCTGCCGGAGCGGATCGCCTGGGCGGTGCT
CGAATTCTGTTCGGGTCCGCTCGCCGAGAACCCGCATCGAGTGGGAAAACCACTGATCGGTGACCTCGCGGGTCTGCACT
CGGCCCGTCGCGGCGAATACCGGGTCATCTACGCCATCTACGACGAGAGGGTTGTCGTGGAAGTCGCGACGGTGCGTCAT
CGCGGCACCGCCTACCGGCCGAGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT166676 WP_001259255.1 NZ_CP058355:1762342-1762593 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT166676 NZ_CP074371:3912178-3912465 [Nocardia tengchongensis]
ATGACTACTTGCTTGCCGCTCGCCGAGGTTCGTGACCGTCTATCGCCGCTGGTCAGTTCCGTCCAGACCACGCATGAACG
GGTGGTCATCACCAAGAACGGCCACCCGGCCGCTGTCCTCATCGCCTACGAGGATCTCGAATCCTTGCAGGAGACAGTGG
AGATCCTTGCCGATCCCGGGATCGTCGACGAGATCCGTGCGGCTCTGGCCGAGCCGGAGCGCTTCACCCTCGAGGACATT
CGGAGGGACCTCGAGGCTCGCGGCGGGTCCGAGGACGGTGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References