Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 778208..778773 Replicon chromosome
Accession NZ_CP058349
Organism Pseudomonas sp. ABC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HW090_RS03305 Protein ID WP_179112141.1
Coordinates 778495..778773 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HW090_RS03300 Protein ID WP_179112140.1
Coordinates 778208..778495 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW090_RS03275 773759..775039 - 1281 WP_179112136.1 hypothetical protein -
HW090_RS03280 775497..775883 - 387 WP_179112137.1 hypothetical protein -
HW090_RS03285 775876..776124 - 249 WP_179112138.1 hypothetical protein -
HW090_RS03290 776117..776305 - 189 WP_179114808.1 helix-turn-helix domain-containing protein -
HW090_RS03295 776887..778161 - 1275 WP_179112139.1 hypothetical protein -
HW090_RS03300 778208..778495 - 288 WP_179112140.1 HigA family addiction module antidote protein Antitoxin
HW090_RS03305 778495..778773 - 279 WP_179112141.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW090_RS03310 779058..779249 - 192 Protein_655 tyrosine-type recombinase/integrase -
HW090_RS03315 779272..779979 - 708 WP_179112142.1 AAA family ATPase -
HW090_RS03320 780049..780477 - 429 WP_179112143.1 hypothetical protein -
HW090_RS03325 780474..781249 - 776 Protein_658 ATP-binding protein -
HW090_RS03330 781246..782139 - 894 WP_179112144.1 phage replication protein -
HW090_RS03335 782139..782360 - 222 WP_179112145.1 hypothetical protein -
HW090_RS03340 782357..782590 - 234 WP_179112146.1 hypothetical protein -
HW090_RS03345 782580..782996 - 417 WP_179112147.1 hypothetical protein -
HW090_RS03350 782993..783427 - 435 WP_179112148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 772160..792150 19990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.25 Da        Isoelectric Point: 9.5915

>T166637 WP_179112141.1 NZ_CP058349:c778773-778495 [Pseudomonas sp. ABC1]
MIKSFQHKGLRKLFETGSTAGVQPSHAKRLRMQLAALDTAMTVDDMDIPGFRLHPLKGEMRGRWSIMVNGNWRLTFEFRD
GNAYVLDYEDYH

Download         Length: 279 bp

>T166637 NZ_CP074364:278529-278663 [Xanthomonas translucens pv. cerealis]
ATGAAGCGTACTTTTGCGTGGATGCTGCTGGCGATGTTTTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10655.19 Da        Isoelectric Point: 7.3184

>AT166637 WP_179112140.1 NZ_CP058349:c778495-778208 [Pseudomonas sp. ABC1]
MNMHNPPHPGEFITDIYLEPNGISGRELAEKLRVAPSTLSRVLKGTSRVTPEMALRLSVALGRSPESWLAMQDTYDLWNA
RQHVDLQQVGRLAFA

Download         Length: 288 bp

>AT166637 NZ_CP074364:278278-278430 [Xanthomonas translucens pv. cerealis]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTCTGTGCAGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
CGGCAAGGATATGCAGAAGGCCGGCGATAAGGTGGAAAACAAGGCCGACGACTGCAAAGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References