Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 447768..448181 Replicon chromosome
Accession NZ_CP058348
Organism Bdellovibrio sp. KM01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HW988_RS02285 Protein ID WP_181607539.1
Coordinates 447768..447905 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HW988_RS02290 Protein ID WP_181607540.1
Coordinates 447921..448181 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW988_RS02265 442953..443816 + 864 WP_181606050.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
HW988_RS02270 443800..444807 + 1008 WP_181606051.1 aspartate-semialdehyde dehydrogenase -
HW988_RS02275 444905..446221 + 1317 WP_181606052.1 hypothetical protein -
HW988_RS02280 446218..447372 + 1155 WP_181606053.1 hypothetical protein -
HW988_RS02285 447768..447905 + 138 WP_181607539.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW988_RS02290 447921..448181 + 261 WP_181607540.1 HigA family addiction module antidote protein Antitoxin
HW988_RS02295 448264..449055 + 792 WP_181606054.1 tRNA pseudouridine(38-40) synthase TruA -
HW988_RS02300 449171..449611 + 441 WP_142698818.1 50S ribosomal protein L13 -
HW988_RS02305 449628..450026 + 399 WP_142698819.1 30S ribosomal protein S9 -
HW988_RS02310 450162..450620 + 459 WP_181606055.1 hypothetical protein -
HW988_RS02315 450653..452776 - 2124 WP_181606056.1 prolyl oligopeptidase family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(13-45)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5468.30 Da        Isoelectric Point: 7.0028

>T166635 WP_181607539.1 NZ_CP058348:447768-447905 [Bdellovibrio sp. KM01]
IALLSWLENLLVKGYYSIRINDQWRITFKWQQDTALEVSIVDYHK

Download         Length: 138 bp

>T166635 NZ_CP074363:c4302051-4301899 [Xanthomonas translucens pv. secalis]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9576.01 Da        Isoelectric Point: 7.0128

>AT166635 WP_181607540.1 NZ_CP058348:447921-448181 [Bdellovibrio sp. KM01]
IEFKNPFHPGEVLLEEFLIPMGISQAAFADKLGWTKAKLNELIKGKRGITAETALDLADQLGTSAKVWMNWQSSFDLDKA
RKDRAG

Download         Length: 261 bp

>AT166635 NZ_CP074363:c4301800-4301666 [Xanthomonas translucens pv. secalis]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References