Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1701440..1702066 Replicon chromosome
Accession NZ_CP058347
Organism Treponema denticola strain OKA3

Toxin (Protein)


Gene name higB Uniprot ID Q73NN6
Locus tag E4N90_RS07980 Protein ID WP_002677634.1
Coordinates 1701440..1701748 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4N90_RS07985 Protein ID WP_002670672.1
Coordinates 1701758..1702066 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N90_RS07955 (E4N90_07945) 1697396..1697733 + 338 Protein_1553 STAS domain-containing protein -
E4N90_RS07960 (E4N90_07950) 1697750..1698292 + 543 WP_002670683.1 ATP-binding protein -
E4N90_RS07965 (E4N90_07955) 1698307..1699128 - 822 WP_253701650.1 hypothetical protein -
E4N90_RS07970 (E4N90_07960) 1699109..1699729 - 621 WP_002686019.1 hypothetical protein -
E4N90_RS07975 (E4N90_07965) 1699845..1701224 + 1380 WP_002670676.1 tyrosine phenol-lyase -
E4N90_RS07980 (E4N90_07970) 1701440..1701748 + 309 WP_002677634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N90_RS07985 (E4N90_07975) 1701758..1702066 + 309 WP_002670672.1 NadS family protein Antitoxin
E4N90_RS07990 (E4N90_07980) 1702199..1702870 + 672 WP_002671738.1 TetR/AcrR family transcriptional regulator -
E4N90_RS07995 (E4N90_07985) 1702959..1703375 + 417 WP_245522456.1 SRPBCC family protein -
E4N90_RS08000 (E4N90_07990) 1703507..1704136 - 630 WP_253701652.1 adenylate kinase -
E4N90_RS08005 (E4N90_07995) 1704195..1705424 - 1230 WP_002670666.1 cation:dicarboxylase symporter family transporter -
E4N90_RS08010 (E4N90_08000) 1705463..1706782 - 1320 WP_002670665.1 leucine-rich repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11736.96 Da        Isoelectric Point: 10.6864

>T166634 WP_002677634.1 NZ_CP058347:1701440-1701748 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Download         Length: 309 bp

>T166634 NZ_CP074363:c4301800-4301666 [Xanthomonas translucens pv. secalis]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11533.43 Da        Isoelectric Point: 9.6884

>AT166634 WP_002670672.1 NZ_CP058347:1701758-1702066 [Treponema denticola]
MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPARVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Download         Length: 309 bp

>AT166634 NZ_CP074363:c4302051-4301899 [Xanthomonas translucens pv. secalis]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q73NN6

Antitoxin

Source ID Structure

References