Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3407929..3408610 Replicon chromosome
Accession NZ_CP058332
Organism Pseudomonas aeruginosa strain B18

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B18_RS15735 Protein ID WP_015503432.1
Coordinates 3407929..3408294 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B18_RS15740 Protein ID WP_003145733.1
Coordinates 3408287..3408610 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B18_RS15705 3403925..3404359 - 435 WP_003116494.1 RidA family protein -
B18_RS15710 3404580..3405533 + 954 WP_003085661.1 LysR family transcriptional regulator -
B18_RS15715 3405506..3406390 - 885 WP_003114205.1 LysR family transcriptional regulator -
B18_RS15720 3406491..3406916 + 426 WP_003114206.1 ring-cleaving dioxygenase -
B18_RS15725 3406947..3407219 - 273 WP_023104842.1 hypothetical protein -
B18_RS15730 3407426..3407665 + 240 WP_044060930.1 hypothetical protein -
B18_RS15735 3407929..3408294 + 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B18_RS15740 3408287..3408610 + 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
B18_RS15745 3408986..3410074 - 1089 WP_003145732.1 DUF3396 domain-containing protein -
B18_RS15750 3410091..3410792 - 702 WP_023110332.1 VRR-NUC domain-containing protein -
B18_RS15755 3410789..3411307 - 519 WP_031629200.1 PAAR domain-containing protein -
B18_RS15760 3411481..3411816 - 336 WP_003140884.1 TM2 domain-containing protein -
B18_RS15765 3412059..3412697 - 639 WP_003163192.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3405506..3420613 15107


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T166583 WP_015503432.1 NZ_CP058332:3407929-3408294 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T166583 NZ_CP074356:874111-874518 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGTTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCAAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT166583 WP_003145733.1 NZ_CP058332:3408287-3408610 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT166583 NZ_CP074356:873864-874130 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References