Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2758533..2759101 Replicon chromosome
Accession NZ_CP058321
Organism Halomonas sp. SH5A2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HXW73_RS12915 Protein ID WP_186253486.1
Coordinates 2758823..2759101 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXW73_RS12910 Protein ID WP_186253485.1
Coordinates 2758533..2758814 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXW73_RS12890 2753998..2754786 - 789 WP_186253481.1 siderophore-iron reductase FhuF -
HXW73_RS12895 2754783..2756783 - 2001 WP_186253482.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
HXW73_RS12900 2756959..2757891 + 933 WP_186253483.1 siderophore-interacting protein -
HXW73_RS12905 2757884..2758516 + 633 WP_186253484.1 cytochrome b -
HXW73_RS12910 2758533..2758814 - 282 WP_186253485.1 HigA family addiction module antidote protein Antitoxin
HXW73_RS12915 2758823..2759101 - 279 WP_186253486.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXW73_RS12920 2759137..2760784 - 1648 Protein_2512 cyclic peptide export ABC transporter -
HXW73_RS12925 2761398..2762090 + 693 WP_186256018.1 acetyltransferase -
HXW73_RS12930 2762114..2763406 + 1293 WP_186253487.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10577.05 Da        Isoelectric Point: 10.2602

>T166549 WP_186253486.1 NZ_CP058321:c2759101-2758823 [Halomonas sp. SH5A2]
MIKSFRHKGLRKFFETGSTSGIQAKHATKLQIQLTALDSAKGPEDMNAPGWRLHPLSHKLKGHWSITVNRNWRLTFAFEG
EDAILVDYQDYH

Download         Length: 279 bp

>T166549 NZ_CP074350:c3802391-3802215 [Pantoea dispersa]
TTGAGCAGCAGGGAGCTGATTAGGATGTTGCTTGAACGAGGGTGGATTCTGGATCGTGTTAAAGGAAGCCATCATGTGTT
TGTCCGTGCAGATAAGCCATATCACATCTCGCTTCCTCATCCTGAAAAAGACCTGGCAACCGGAACATTACGTAAGCTAT
TGAAAATGATGGACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10166.63 Da        Isoelectric Point: 8.6800

>AT166549 WP_186253485.1 NZ_CP058321:c2758814-2758533 [Halomonas sp. SH5A2]
MNRMHNPAHPGAVLREYIGDISVTQAAQQLGVTRTALSRILNGNAGISADMALRLEQALGTSAEMWLEMQLKYELWQASQ
RPRAQVSPLHAAG

Download         Length: 282 bp

>AT166549 NZ_CP074350:c3802096-3801692 [Pantoea dispersa]
ATGAGATTCCCCGTTTATTTGCACAAAACAGAAAACGGCAGCTGGTCAGGTTTCGTACCCGACGTGCAGGGATGTTTTTT
TGCGGGCAACACCGTTGACGAGGCGTTGAGCGATGCATTTGGTGCAATCGATGCGCATGTGGAATCGTTAGCGGACGCAG
GCAAGGCCATTCCAAAAGCAGCCAGCGTTGAAACCCATATTAATGATGAAGAGTGCCAGGGAGGTTACTGGGCTTTCGTT
GAGATTGATCTCAGTCGTTACGAAGGTAAAGCGGTGAAGCTGAACATCACCCTGCCGCAAAACTTACTGACCAAAATCGA
TAGCCACGTAGAAGCACACCGCGAATACGGCTCCCGTAGCGGCTTTCTCGCCGCGCTGGCACGCAGAGAACTGGCAAACA
TCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References