Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2136365..2136936 Replicon chromosome
Accession NZ_CP058321
Organism Halomonas sp. SH5A2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HXW73_RS09990 Protein ID WP_186252972.1
Coordinates 2136658..2136936 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXW73_RS09985 Protein ID WP_186252971.1
Coordinates 2136365..2136658 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXW73_RS09950 2131864..2132178 - 315 WP_186252966.1 HigA family addiction module antidote protein -
HXW73_RS09955 2132193..2132472 - 280 Protein_1933 type II toxin-antitoxin system RelE/ParE family toxin -
HXW73_RS09960 2132647..2133714 - 1068 WP_186252967.1 hypothetical protein -
HXW73_RS09965 2133807..2134397 - 591 WP_186255982.1 DUF2971 domain-containing protein -
HXW73_RS09970 2134480..2135208 - 729 WP_186252968.1 hypothetical protein -
HXW73_RS09975 2135306..2135551 - 246 WP_186252969.1 hypothetical protein -
HXW73_RS09980 2135851..2136282 - 432 WP_186252970.1 GFA family protein -
HXW73_RS09985 2136365..2136658 - 294 WP_186252971.1 HigA family addiction module antidote protein Antitoxin
HXW73_RS09990 2136658..2136936 - 279 WP_186252972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXW73_RS09995 2137047..2137853 - 807 WP_186252973.1 IS21-like element helper ATPase IstB -
HXW73_RS10000 2137850..2139031 - 1182 WP_186252974.1 IS21 family transposase -
HXW73_RS10005 2139189..2139773 - 585 WP_186255983.1 AbiV family abortive infection protein -
HXW73_RS10015 2140976..2141128 - 153 WP_186252976.1 hypothetical protein -
HXW73_RS10020 2141179..2141655 - 477 WP_186252977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2131234..2142854 11620


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10700.18 Da        Isoelectric Point: 10.0256

>T166548 WP_186252972.1 NZ_CP058321:c2136936-2136658 [Halomonas sp. SH5A2]
MIKSFRHKGLKRFYSTGNTSGIQPDHAKKLRMQLAALDTATAVEDMEIPGFRLHPLKGKDKGRWSIRVNGNWRITFEFQD
GNAYILDYEDYH

Download         Length: 279 bp

>T166548 NZ_CP074350:c3739645-3739346 [Pantoea dispersa]
ATGATTGAGGATGTGTTGGCCAGCCTAGCGGTTCTCAGGGAGTTCGGGCCCACGTTAGGGCGGCCTGATGTTGATACCCT
CGTCGGGTCGCGTTTTTCCAATATGAAAGAACTCCGTGTTCAGAGTAATGGCCGGGCGATTCGTGCGTTTTTTGCCTTCG
ATCCGGTCAGACGGGCCATTGTGCTCTGCGCGGGAAACAAAACCGGAACGCATCAGCGGCGCTTTTATCAGGCGATGATT
AAACTGGCTGACCGCGAGTATCAACAGCATCTGGAGGAGATGAATCATGCCAAAACTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10754.29 Da        Isoelectric Point: 5.5589

>AT166548 WP_186252971.1 NZ_CP058321:c2136658-2136365 [Halomonas sp. SH5A2]
MTMHNPPHPGEFIREVYLEPFGVSSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWVA
RNTVNLDGIHPLDFEAA

Download         Length: 294 bp

>AT166548 NZ_CP074350:c3739359-3739060 [Pantoea dispersa]
ATGCCAAAACTTGAAGACCTGATTGCTCAGCGTTCGCCTGAATCACAGGCGCGCATCAGAAATAAGGCGGCGGAAAAAAT
CATCGAGATTCGTCTGCGCCAGCTGCGGGAAGAACTGGCGCTTTCACAGGTACAGCTGGCTGAAAAGATGGGTGTTTCGC
AACCTGCTATTGCAGCCATCGAGGCGCGTGGTGACGAACTGAAACTCTCCAGCCTGAAAAAATACGTTGAGGCGTTAGGC
GGAAAATTGAGTGTAACCGTTGAACTGCCAGCCGGTGACGGGCGGATTTTCCAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References