Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 963353..963944 Replicon chromosome
Accession NZ_CP058321
Organism Halomonas sp. SH5A2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HXW73_RS04560 Protein ID WP_186255906.1
Coordinates 963353..963664 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXW73_RS04565 Protein ID WP_186255109.1
Coordinates 963657..963944 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXW73_RS04530 958564..959607 + 1044 WP_186255104.1 DUF3541 domain-containing protein -
HXW73_RS04535 959659..959973 + 315 WP_186255105.1 hypothetical protein -
HXW73_RS04540 960008..961048 - 1041 WP_186255106.1 nucleoside monophosphate kinase -
HXW73_RS04545 961318..962211 + 894 WP_186255107.1 dihydrodipicolinate synthase family protein -
HXW73_RS04550 962383..963078 + 696 WP_186255108.1 haloacid dehalogenase type II -
HXW73_RS04555 963137..963244 + 108 Protein_881 PhnA domain-containing protein -
HXW73_RS04560 963353..963664 + 312 WP_186255906.1 transcriptional regulator Toxin
HXW73_RS04565 963657..963944 + 288 WP_186255109.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
HXW73_RS04570 964472..965521 + 1050 WP_186255110.1 DUF2235 domain-containing protein -
HXW73_RS04575 965617..965952 + 336 WP_186255111.1 PhnA domain-containing protein -
HXW73_RS04580 966072..966401 + 330 WP_186255112.1 DUF427 domain-containing protein -
HXW73_RS04585 966515..968155 + 1641 WP_186255113.1 RNA-directed DNA polymerase -
HXW73_RS04590 968142..968897 + 756 WP_186255114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 958564..971450 12886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-96)

Antitoxin

Antitoxin MqsA/HigA-2

(33-94)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11567.35 Da        Isoelectric Point: 9.9940

>T166546 WP_186255906.1 NZ_CP058321:963353-963664 [Halomonas sp. SH5A2]
MLFIETSAFTKLLPNYLTDEEYRGLQVYLLQKPDAGDLIKGSGGVRKVRWSSAGSGKSGGVRAIYYWKKSDHEIWMLTLY
SKTERASIPGHMLKQIAEAIKNG

Download         Length: 312 bp

>T166546 NZ_CP074350:2594670-2594852 [Pantoea dispersa]
ATGAAGAGCGCGACGCTGATTAAACTGCTGCAAAAGAATGGCTGGAAGCTGGAGCGCATACGCGGCAGTCATCATCAGTT
CTCGCACCCGGATTTTGCTCATCTGATCACCGTGCCGCATCCGCAGAAGGATATGAAGACAGGCACGCTGATGCAGATTC
TGAAAGACGCCAGGCTGGATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10672.23 Da        Isoelectric Point: 6.8807

>AT166546 WP_186255109.1 NZ_CP058321:963657-963944 [Halomonas sp. SH5A2]
MVDRNLGAEILDGIDEIKQFKKGNVALRTHELAEPSPPKIIRHKLNLSQSAFAGLLGVSMRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFDQLH

Download         Length: 288 bp

>AT166546 NZ_CP074350:2594892-2595284 [Pantoea dispersa]
ATGCTGTTTCCCGCTTTGGTAGAGATTGACGCTGACGGCTCGGCCAGTGGTTATTTCCCGGATGTCACCGGCTGTTATTT
TGCCGGTGATACGCCCGAGCAAACGCTGCAGGATGCGCAATCTGCGCTGCATGCCCACTTTGAACTGATGGCGGAGAAAG
GCTTATTGATTCCGGAGCCGGCGCAGCACTGGCAGCAGGAATTTAGCCAGCCCGGCGTGTGGATCTACGTTGATATTGAT
GTCACCCGCTATCTGGGCAAATCCGAGCGCATCAATATCACTATGCCGCATCTGCTGATTGAGAAGATCGATAAGATGGT
CAGTAATAACGCGCGCTACAGCAGCCGCAGCCATTTTCTTGCCGAGGCGGCACGCAAAGCGCTGGTCTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References