Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 823774..824474 Replicon chromosome
Accession NZ_CP058315
Organism Treponema parvum strain OMZ 843

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HXT04_RS03760 Protein ID WP_210122043.1
Coordinates 824163..824474 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXT04_RS03755 Protein ID WP_256729188.1
Coordinates 823774..824079 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT04_RS03745 (HXT04_03740) 819697..822315 - 2619 WP_210122041.1 ATP-dependent RNA helicase -
HXT04_RS03750 (HXT04_03745) 822427..823452 - 1026 WP_210122042.1 phosphate acetyltransferase -
HXT04_RS03755 (HXT04_03750) 823774..824079 - 306 WP_256729188.1 NadS family protein Antitoxin
HXT04_RS03760 (HXT04_03755) 824163..824474 - 312 WP_210122043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXT04_RS03765 (HXT04_03760) 824756..825115 + 360 WP_210122044.1 polymer-forming cytoskeletal protein -
HXT04_RS03770 (HXT04_03765) 825222..825860 + 639 WP_210122045.1 tetratricopeptide repeat protein -
HXT04_RS03775 (HXT04_03770) 825860..827482 + 1623 WP_210122046.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
HXT04_RS03780 (HXT04_03775) 827519..828520 - 1002 WP_210122047.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12058.26 Da        Isoelectric Point: 10.3875

>T166540 WP_210122043.1 NZ_CP058315:c824474-824163 [Treponema parvum]
MELIETSIFKKRIDQLLDGITYAQFREYLVCNPLRGKLIRHGGGIRKIRWKTKYTGKSSGIRIIYFIKSNTKIYLLYCYA
KNQAGDLTREQIKDLALLVKDLQ

Download         Length: 312 bp

>T166540 NZ_CP074348:c1296213-1295467 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAAGCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11498.41 Da        Isoelectric Point: 10.2428

>AT166540 WP_256729188.1 NZ_CP058315:c824079-823774 [Treponema parvum]
MLKKRMPNEMFDELKQSVKEAISIEEGKMKPSRVFHIEPLDISEIRNKTNKTQEEFAAMLNVSVGTLRNWEQGRRKPAGA
ALSLLKIVSADPQYVKNVLVT

Download         Length: 306 bp

>AT166540 NZ_CP074348:c1295466-1295296 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References