Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2662341..2662864 Replicon chromosome
Accession NZ_CP058312
Organism Staphylococcus aureus strain BLR-DV

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag HW113_RS13430 Protein ID WP_000074048.1
Coordinates 2662341..2662607 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag HW113_RS13435 Protein ID WP_000587616.1
Coordinates 2662607..2662864 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW113_RS13410 2657648..2658835 - 1188 WP_000026194.1 MFS transporter -
HW113_RS13415 2659231..2660007 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
HW113_RS13420 2660000..2660662 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
HW113_RS13425 2660910..2661986 - 1077 WP_001076671.1 M42 family metallopeptidase -
HW113_RS13430 2662341..2662607 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
HW113_RS13435 2662607..2662864 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HW113_RS13440 2662970..2663164 - 195 WP_001790145.1 hypothetical protein -
HW113_RS13445 2663223..2663678 + 456 WP_000732082.1 DUF1307 domain-containing protein -
HW113_RS13450 2663846..2665423 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
HW113_RS13455 2665618..2666367 + 750 WP_000072442.1 hypothetical protein -
HW113_RS13460 2666591..2667784 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T166538 WP_000074048.1 NZ_CP058312:c2662607-2662341 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T166538 NZ_CP074347:4693708-4694187 [Serratia entomophila]
ATGATTATTCTCGACACCAACGTCATGTCAGAAACGCTGCGCCCCAGTCCGCACTACAACGTCATAAACTGGTTAAACGA
AAAGGACAATGACGAGCTCTACCTGAGCGCCATTGTCATTGCCGAGCTGTTCAGCGGCGTCGCCTGCATGCCTGACGGCA
AGCGTCAGCGGGATCTGAAGCTCAAATTGGCGGACGCCATCCAGCTGAAGTTCGAAGGGCAAATTCTGCCGTTTGACGGG
CTGTGCGCGATGCAATACGCGGAGTTGACGGGAAGAAACCGGCTTCAGGGCAAGCTGATGAGCATGCCAGACACGCAAAT
CGCCGCCACCTGCCTGCATTACGGCGCCACATTGGCCACACGCAATACGCAAGACTTTCTCCACTGCGGCATCGAATTAA
TCGATCCGTGGCAGGCTCCGACCGGCCGCCGTCTGCATGAAGACGCGGCGGAATACTACGTGATGAGCCGGAAGTCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT166538 WP_000587616.1 NZ_CP058312:c2662864-2662607 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT166538 NZ_CP074347:4693448-4693711 [Serratia entomophila]
ATGGCTACCATAACCGTCAGGAATTTGGACGATGAGATAAAAGAGCTGCTGCGCATTTCGGCAGCGAAAAATGGCCATTC
CATGGAGGAAGAAGCAAGAATGATCCTGAAACAGGCGCTGGTGAAAAAGCCGCCGCGCTACGGGTTGGGTACCTGGATGC
ATCAGCACTTCGCCGAATTTGGCGGCGTCGAGCTGGACATTCCGCCGCGAGACGCCGTGCCGCCTCGCATAGTCAGCTTT
GATGATGAAGATGGCAACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References