Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2605490..2606007 | Replicon | chromosome |
| Accession | NZ_CP058312 | ||
| Organism | Staphylococcus aureus strain BLR-DV | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | HW113_RS13155 | Protein ID | WP_000113262.1 |
| Coordinates | 2605490..2605756 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | HW113_RS13160 | Protein ID | WP_000584499.1 |
| Coordinates | 2605756..2606007 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HW113_RS13125 | 2600916..2601452 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| HW113_RS13130 | 2601685..2602509 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| HW113_RS13135 | 2602726..2602908 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| HW113_RS13140 | 2602992..2603459 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| HW113_RS13145 | 2603645..2605195 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| HW113_RS13150 | 2605384..2605455 | - | 72 | Protein_2549 | hypothetical protein | - |
| HW113_RS13155 | 2605490..2605756 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| HW113_RS13160 | 2605756..2606007 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HW113_RS13165 | 2606172..2606273 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| HW113_RS13170 | 2606280..2606879 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| HW113_RS13175 | 2606898..2607260 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| HW113_RS13180 | 2607515..2608765 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| HW113_RS13185 | 2608862..2609593 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| HW113_RS13190 | 2609590..2610309 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T166535 WP_000113262.1 NZ_CP058312:c2605756-2605490 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T166535 NZ_CP074347:c4063379-4062957 [Serratia entomophila]
GTGGCCCAGTGGCGATGTGACGTCCGCGTTTCCTGGCGCACCCAGTTATTCTCGCTGCTGACGCATGGCCTGCTGATCCT
CCTGATCCTGGTTTCGCCCTGGCCGGAAGGCTTTTGGGTTATCTGGTTGGTGCTGCTGACGCTGGTGGTGTTCCAATGCA
TCCGTAGCCAGAAGCGCATCGCTGCGGTGCAGGGCGAGTTGCGCCTGCTGGCGGATCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCTGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCATGTTGCTGACGCTGCAGCCGATGGAGGGGAAAAAACG
CCGTCGTTTGTGGCTGGCTTCAGACAGCATGAGCAAGGAAGAATGGCGGCATCTGCGTCAGTTGCTGCTGTACCCGCCTG
CCGGCGATGACGAGGACGCCTGA
GTGGCCCAGTGGCGATGTGACGTCCGCGTTTCCTGGCGCACCCAGTTATTCTCGCTGCTGACGCATGGCCTGCTGATCCT
CCTGATCCTGGTTTCGCCCTGGCCGGAAGGCTTTTGGGTTATCTGGTTGGTGCTGCTGACGCTGGTGGTGTTCCAATGCA
TCCGTAGCCAGAAGCGCATCGCTGCGGTGCAGGGCGAGTTGCGCCTGCTGGCGGATCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCTGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCATGTTGCTGACGCTGCAGCCGATGGAGGGGAAAAAACG
CCGTCGTTTGTGGCTGGCTTCAGACAGCATGAGCAAGGAAGAATGGCGGCATCTGCGTCAGTTGCTGCTGTACCCGCCTG
CCGGCGATGACGAGGACGCCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT166535 WP_000584499.1 NZ_CP058312:c2606007-2605756 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT166535 NZ_CP074347:c4063626-4063360 [Serratia entomophila]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACCAGCTGAATGACACGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGGCCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA
ATGGATATTAATAACAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACCAGCTGAATGACACGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGGCCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|