Detailed information of TA system TA166531

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2337189..2337468
• Replicon: chromosome
• Accession: NZ_CP058312
• Organism: Staphylococcus aureus strain BLR-DV

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: HW113_RS11750
• Protein ID: WP_001802298.1
• Coordinates: 2337364..2337468 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2337189..2337368 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW113_RS11730	2333388..2334053	-	666	WP_001024094.1	SDR family oxidoreductase	-
HW113_RS11735	2334205..2334525	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
HW113_RS11740	2334527..2335507	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
HW113_RS11745	2335773..2336864	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2337189..2337368	+	180	-	-	Antitoxin
HW113_RS11750	2337364..2337468	-	105	WP_001802298.1	hypothetical protein	Toxin
HW113_RS11755	2337629..2338112	-	484	Protein_2279	recombinase family protein	-
HW113_RS11760	2338155..2339291	-	1137	WP_000115564.1	SAP domain-containing protein	-
HW113_RS11765	2339580..2339672	+	93	WP_001790138.1	hypothetical protein	-
HW113_RS11770	2339919..2341091	-	1173	WP_000195429.1	IS256-like element IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2339919..2341091	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T166531 WP_001802298.1 NZ_CP058312:c2337468-2337364 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T166531 NZ_CP074347:518709-518984 [Serratia entomophila]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGAGCAGGCTGATAACGAGATCGATAAAGCGGTAAAGCGCCTGCTGGATCATCCTGAGTTAGGTAAGCCCTGGTATG
GGAAGGCACGTAAGCTGCTAATTAACAAGGCCTCCCTGTTGCTGGTGTATATCATCGTTGATGACGTTATTAAGGTTTTC
TCGATTGCCCACCAGCGTGAGAAATTTCCAAACTAG

Antitoxin

Nucleotide

• Length: 180 bp

>AT166531 NZ_CP058312:2337189-2337368 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin