Detailed information of TA system TA166526

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1027571..1027753
• Replicon: chromosome
• Accession: NZ_CP058312
• Organism: Staphylococcus aureus strain BLR-DV

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: HW113_RS05315
• Protein ID: WP_001801861.1
• Coordinates: 1027658..1027753 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1027571..1027630 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW113_RS05300	1026709..1027086	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
HW113_RS05305	1027280..1027456	+	177	Protein_1000	transposase	-
HW113_RS05310	1027434..1027535	-	102	WP_001791893.1	hypothetical protein	-
-	1027571..1027630	+	60	-	-	Antitoxin
HW113_RS05315	1027658..1027753	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
HW113_RS05320	1027956..1028099	+	144	WP_001549059.1	transposase	-
HW113_RS05325	1028703..1029086	+	384	WP_000070811.1	hypothetical protein	-
HW113_RS05330	1029097..1029273	+	177	WP_000375476.1	hypothetical protein	-
HW113_RS05335	1029275..1029460	+	186	WP_000809857.1	hypothetical protein	-
HW113_RS05340	1029574..1030215	+	642	WP_112366573.1	ImmA/IrrE family metallo-endopeptidase	-
HW113_RS05345	1030433..1030984	-	552	WP_000414205.1	hypothetical protein	-
HW113_RS05350	1031082..1031426	-	345	WP_000627551.1	DUF3969 family protein	-
HW113_RS05355	1031467..1032093	-	627	WP_000669046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	995501..1065193	69692

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T166526 WP_001801861.1 NZ_CP058312:c1027753-1027658 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T166526 NZ_CP074346:c907694-907398 [Pasteurella atlantica]
ATGAAGCTTGATGATTTAAAAGAATTTGATGCATCTAAATATTTAGTGGATGAAGAATCTATTGCAATTTATGTAAATGA
AATGCTTGAAAGTGGTGATTTAAAAGCGTTACCACTTGCATTAGGGACTGTTTCAAAAGCACGTAATATGAGTGAACTTT
CTCGTAAAACAGGGATTAGTCGTAAAGGGTTATATCAAGCATTATCAGAAGATGGCAACCCTAGTTTTGATACCGTTTTA
AAAGTAATGCAAGCGTTAAATTTGACTTTTGAAATTAAACAAAAACAAGTTATATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT166526 NZ_CP058312:1027571-1027630 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin