Detailed information of TA system TA166522

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 866840..867178
• Replicon: chromosome
• Accession: NZ_CP058312
• Organism: Staphylococcus aureus strain BLR-DV

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: HW113_RS04320
• Protein ID: WP_072482930.1
• Coordinates: 866840..867016 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	867004..867178 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW113_RS04300	864669..864821	+	153	WP_001000058.1	hypothetical protein	-
HW113_RS04305	864868..865155	+	288	WP_001040259.1	hypothetical protein	-
HW113_RS04310	865211..865585	+	375	WP_000340977.1	hypothetical protein	-
HW113_RS04315	865958..866731	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
HW113_RS04320	866840..867016	+	177	WP_072482930.1	putative holin-like toxin	Toxin
-	867004..867178	-	175	-	-	Antitoxin
HW113_RS04330	867228..867482	+	255	WP_000611512.1	phage holin	-
HW113_RS04335	867494..868177	+	684	WP_049881763.1	CHAP domain-containing protein	-
HW113_RS04340	868440..868931	+	492	WP_000920041.1	staphylokinase	-
HW113_RS04345	869583..869918	+	336	Protein_848	SH3 domain-containing protein	-
HW113_RS04350	870428..870778	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
HW113_RS04355	870831..871091	-	261	WP_001791826.1	hypothetical protein	-
HW113_RS04360	871401..871580	-	180	WP_000669789.1	hypothetical protein	-
HW113_RS04365	871902..872152	-	251	Protein_852	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sea / sak / scn	822969..870778	47809

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T166522 WP_072482930.1 NZ_CP058312:866840-867016 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T166522 NZ_CP074233:1860977-1861080 [Salmonella bongori CFSAN000510]
GGCAGGGCGACTTAACCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 175 bp

>AT166522 NZ_CP058312:c867178-867004 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin